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P5296

Sigma-Aldrich

CTOP

≥97% (HPLC)

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About This Item

经验公式（希尔记法）:
C50H67N11O11S2
CAS号:
103429-31-8
分子量:
1062.26
MDL號碼:
MFCD00076708
分類程式碼代碼:
12352200
PubChem物質ID:
329820226
NACRES:
NA.77

品質等級

100

化驗

≥97% (HPLC)

形狀

powder

UniProt登錄號

Q64387

儲存溫度

−20°C

SMILES 字串

C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O

InChI

1S/C50H67N11O11S2/c1-26(62)39(42(53)65)59-49(72)41-50(3,4)74-73-25-38(58-43(66)33(52)21-28-11-6-5-7-12-28)47(70)56-36(22-29-16-18-31(64)19-17-29)45(68)57-37(23-30-24-54-34-14-9-8-13-32(30)34)46(69)55-35(15-10-20-51)44(67)60-40(27(2)63)48(71)61-41/h5-9,11-14,16-19,24,26-27,33,35-41,54,62-64H,10,15,20-23,25,51-52H2,1-4H3,(H2,53,65)(H,55,69)(H,56,70)(H,57,68)(H,58,66)(H,59,72)(H,60,67)(H,61,71)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

InChI 密鑰

PZWWYAHWHHNCHO-FGHAYEPSSA-N

基因資訊

mouse ... Pnoc(18155)

Amino Acid Sequence

Phe-Cys-Tyr-Trp-Orn-Thr-Pen-Thr-NH2 [Disulfide Bridge: 2-7]

一般說明

D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2（CTOP）是一种选择性的环状μ-阿片受体拮抗剂。

應用

CTOP已用于：
  • 研究CTOP对小鼠和大鼠的抗焦虑作用。
  • 研究μ-阿片受体拮抗剂CTOP对牛乳源性LF（BLF）镇痛作用的影响。
  • 确定μ-阿片受体是否与5-羟色胺（5-HT1A）受体协同作用，以调节在高架T迷宫（ETM）中产生的行为。

生化／生理作用

μ阿片受体的选择性配体。
D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2（CTOP）在体内以剂量依赖性方式抑制急性吗啡诱导的运动过度和吗啡的镇痛作用。

聯結

生长抑素类似物

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCD2654
BCBT1953
BCBL8678V
BCBL8678
SLBF4367V

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G T C Wong et al.
Acta anaesthesiologica Scandinavica, 54(4), 510-518 (2009-11-03)
Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective mu opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion injury. This study investigates whether remifentanil post-conditioning is also
Céline Heinl et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16748-16756 (2011-11-18)
In addition to analgesia, opioids may also produce paradoxical pain amplification [opioid-induced hyperalgesia (OIH)] either on abrupt withdrawal or during continuous long-term application. Here, we assessed antinociceptive and pronociceptive effects of three clinically used opioids at C-fiber synapses in the
Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and ?-receptors.
Roncon CM
Journal of Psychopharmacology, 27(12), 1141-1148 (2013)
Garrett J Gross et al.
American journal of physiology. Heart and circulatory physiology, 298(6), H2201-H2207 (2010-04-20)
We previously demonstrated that several epoxyeicosatrienoic acids (EETs) produce reductions in myocardial infarct size in rats and dogs. Since a recent study demonstrated the release of opioids in mediating the antinociceptive effect of 14,15-EET, we hypothesized that endogenous opioids may
Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
Gulya K
European Journal of Pharmacology, 150(3), 355-360 (1988)
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