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C6352

Sigma-Aldrich

CTAP

≥95%

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About This Item

经验公式（希尔记法）:
C51H69N13O11S2
CAS号:
103429-32-9
分子量:
1104.30
MDL號碼:
MFCD00671434
分類程式碼代碼:
12352200
PubChem物質ID:
329775120
NACRES:
NA.32

品質等級

200

化驗

≥95%

形狀

powder

UniProt登錄號

Q62923

儲存溫度

−20°C

SMILES 字串

C[C@@H](O)[C@H](NC(=O)[C@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CSSC1(C)C)NC(=O)[C@H](N)Cc5ccccc5)[C@@H](C)O)C(N)=O

InChI

1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1

InChI 密鑰

OFMQLVRLOGHAJI-FGHAYEPSSA-N

基因資訊

rat ... Pnoc(25516)

Amino Acid Sequence

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2

應用

CTAP可作为μ-阿片受体 (MOR) 拮抗剂用于：
  • 研究二肽基肽酶4 (DPP4) 抑制剂异亮氨酰-脯氨酰-异亮氨酸 (IPI) 和维格列汀对卡拉胶诱导炎症的抗痛觉过敏作用
  • 研究其在大鼠天敌应激期间对谷氨酸和γ-氨基丁酸 (GABA) 外排的作用
  • 测定在胃泌素释放肽 (Grp+) 神经元活化诱导疼痛阻断中参与的內源性阿片肽

生化／生理作用

CTAP是以生长抑素类似物制备的一种多肽拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Kevin Caref et al.
eLife, 7 (2018-03-28)
When relatively sated, people (and rodents) are still easily tempted to consume calorie-dense foods, particularly those containing fat and sugar. Consumption of such foods while calorically replete likely contributes to obesity. The nucleus accumbens (NAc) opioid system has long been
Chloe M Stanton et al.
Scientific reports, 7(1), 12147-12147 (2017-09-25)
Late-onset retinal degeneration (L-ORD) is a rare autosomal dominant retinal dystrophy, characterised by extensive sub-retinal pigment epithelium (RPE) deposits, RPE atrophy, choroidal neovascularisation and photoreceptor cell death associated with severe visual loss. L-ORD shows striking phenotypic similarities to age-related macular
Laura Milan-Lobo et al.
PloS one, 8(3), e58362-e58362 (2013-04-05)
Delta (DOR) and mu opioid receptors (MOR) can complex as heteromers, conferring functional properties in agonist binding, signaling and trafficking that can differ markedly from their homomeric counterparts. Because of these differences, DOR/MOR heteromers may be a novel therapeutic target
E J Bilsky et al.
The Journal of pharmacology and experimental therapeutics, 277(1), 484-490 (1996-04-01)
Previous studies measuring opioid inhibition of cyclic adenosine monophosphate in SH-SY5Y cells supported the hypothesis that continuous agonist stimulation causes a gradual conversion of the mu opioid receptor to a sensitized or constitutively active state termed mu*. Conversion to mu*
Christine E Engeland et al.
Virology, 460-461, 194-206 (2014-07-11)
Human immunodeficiency virus Gag drives assembly of virions in infected cells and interacts with host factors which facilitate or restrict viral replication. Although several Gag-binding proteins have been characterized, understanding of virus-host interactions remains incomplete. In a series of six
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