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product name
匹莫齐特,
形狀
powder
品質等級
溶解度
DMSO: 18 mg/mL(lit.)
chloroform: 5 mg/mL
H2O: insoluble(lit.)
起源
Teva
儲存溫度
2-8°C
SMILES 字串
Fc1ccc(cc1)C(CCCN2CCC(CC2)N3C(=O)Nc4ccccc34)c5ccc(F)cc5
InChI
1S/C28H29F2N3O/c29-22-11-7-20(8-12-22)25(21-9-13-23(30)14-10-21)4-3-17-32-18-15-24(16-19-32)33-27-6-2-1-5-26(27)31-28(33)34/h1-2,5-14,24-25H,3-4,15-19H2,(H,31,34)
InChI 密鑰
YVUQSNJEYSNKRX-UHFFFAOYSA-N
基因資訊
human ... ABCB1(5243) , CACNA1G(8913) , CYP3A4(1576) , DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816) , HTR2A(3356) , HTR7(3363) , KCNH1(3756) , KCNH2(3757) , OPRD1(4985)
mouse ... Abcb1a(18671) , Abcb1b(18669)
rat ... Scnn1g(24768)
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生化／生理作用
D 2 多巴胺受体拮抗剂；与克隆的 5-HT 7 受体高亲和力结合；Ca 2 + 通道拮抗剂；抗精神病药
特點和優勢
该化合物在受体分类和信号转导手册的环核苷酸门控（CNG）和超极化激活的环核苷酸门控（HCN）通道页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
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The present review gives an overview of current pharmacological treatment options of tic disorders and Tourette Syndrome (TS). After a short summary on phenomenology, clinical course and comorbid conditions we review indications for pharmacological treatment in detail. Unfortunately, standardized and
Sager J Gosai et al.
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The development of preclinical models amenable to live animal bioactive compound screening is an attractive approach to discovering effective pharmacological therapies for disorders caused by misfolded and aggregation-prone proteins. In general, however, live animal drug screening is labor and resource
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