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About This Item
经验公式（希尔记法）:
C8H5NO4S
CAS号:
分子量:
211.19
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: >20 mg/mL
SMILES 字串
[O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
InChI
1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChI 密鑰
ZRRGOUHITGRLBA-UHFFFAOYSA-N
應用
Stattic 用于抑制信号转导子和转录激活因子3（STAT3）的活性，适用各种细胞系和培养物中。
Stattic 用于研究人肺癌细胞中 Stat3 介导的细胞信号传导。5
生化／生理作用
Stattic（Stat3 三抑制化合物）改变 Stat3 的 SH2 结构域，间接抑制与磷肽结合。与其他磷酸肽类相比，它易于跨膜转运。2 Stattic 诱导 ROS 形成增加，对心肌细胞线粒体功能产生负面影响， 3 并使鼻咽癌细胞对放化疗敏感。4
Stattic 是一种不可逆的 STAT3 活化抑制剂。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Matthew A Bill et al.
Molecular cancer, 9, 165-165 (2010-06-26)
We characterized the biologic effects of a novel small molecule STAT3 pathway inhibitor that is derived from the natural product curcumin. We hypothesized this lead compound would specifically inhibit the STAT3 signaling pathway to induce apoptosis in melanoma cells. FLLL32
Doyeon Park et al.
Journal of breast cancer, 24(2), 138-152 (2021-04-06)
Melanoma-associated antigen C2 (MAGEC2) is an oncogene associated with various types of cancers. However, the biological function of MAGEC2 in circulating tumor cells remains unclear. In this study, we investigated the role of MAGEC2 using adapted suspension cells (ASCs), which
Long noncoding RNA PVT1 promotes hepatoblastoma cell proliferation through activating STAT3
Luo Z and Cao P
Cancer Management and Research, 11, 8517-8517 (2019)
Human dental pulp stem cells grown in neurogenic media differentiate into endothelial cells and promote neovasculogenesis in the mouse brain.
Luzuriaga J, et al.
Frontiers in Physiology, 10, 347-347 (2019)
Kerstin Boengler et al.
Current pharmaceutical design, 19(39), 6890-6895 (2013-04-18)
The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration
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