化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
protect from light
溶解度
DMSO: >20 mg/mL
起源
Johnson & Johnson
儲存溫度
2-8°C
SMILES 字串
COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1
InChI
1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
InChI 密鑰
GXDALQBWZGODGZ-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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生化/生理作用
阿司咪唑是一种强效 hERG 钾通道阻断剂(IC 50 为 0.9 nM),可用作药理学分子伴侣,以纠正折叠缺陷并恢复一些 hERG 通道突变形式的蛋白功能。它还被研究用于治疗疟疾、癌症中的 hERG 和 hEAG 通道功能以及作为第二代抗组胺药 H-1 拮抗剂。
特點和優勢
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表,请点击此处。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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