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About This Item
线性分子式:
C23H46NO4 · Cl
CAS号:
分子量:
436.07
Beilstein:
4071005
EC號碼:
MDL號碼:
分類程式碼代碼:
12352211
PubChem物質ID:
NACRES:
NA.25
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品質等級
化驗
≥98% (TLC)
形狀
powder
顏色
white
溶解度
H2O: 25 mg/mL (with heat or sonication)
脂質類型
saturated FAs
儲存溫度
−20°C
SMILES 字串
[Cl-].CCCCCCCCCCCCCCCC(=O)O[C@H](CC(O)=O)C[N+](C)(C)C
InChI
1S/C23H45NO4.ClH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-23(27)28-21(19-22(25)26)20-24(2,3)4;/h21H,5-20H2,1-4H3;1H/t21-;/m1./s1
InChI 密鑰
GAMKNLFIHBMGQT-ZMBIFBSDSA-N
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應用
棕榈酰-L-肉碱氯化物已用作酰基肉碱，用于处理心肌细胞以诱导活性氧（ROS）。
生化／生理作用
长链酰基肉碱和知名的线粒体脂肪酸氧化的中间体。改变心脏中高能磷酸盐和游离脂肪酸的心肌水平。增加培养物中红系菌落的形成。减少红细胞和心肌细胞的表面负电荷。据报道，通过抑制内皮细胞中的胞内钙信号传导，以剂量依赖的方式影响电流并抑制乙酰胆碱和 P 物质诱导的内皮依赖性舒张。抑制 Na/K 泵电流，但对豚鼠心室细胞的胞内钙电流没有影响。但是，与卵白蛋白一样，它可逆地使静息膜去极化，减少动作电位持续时间，并增加心肌细胞收缩的幅度。
訊號詞
Warning
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Sriram Devanathan et al.
Biology of sex differences, 7, 25-25 (2016-05-18)
Cardiovascular disease is the leading cause of death among diabetic patients. Importantly, recent data highlight the apparent sexual dimorphism in the pathogenesis of cardiovascular disease in diabetics with respect to both frequency- and age-related risk factors. The disposition to cardiovascular
M Matsumura et al.
American journal of nephrology, 18(5), 355-358 (1998-09-08)
The administration of L-carnitine to patients undergoing hemodialysis increases hematocrit and improves the response to recombinant human erythropoietin (rhEPO). This suggests a contribution by carnitine to erythrocyte membrane function or erythropoiesis. We investigated the effect of L-carnitine and palmitoyl-L-carnitine on
S R Stapleton et al.
British journal of pharmacology, 107(4), 1192-1197 (1992-12-01)
1. The effects of palmitoyl-DL-carnitine (0.01 to 1 mM) on whole cell voltage-activated calcium channel currents carried by calcium or barium and Ca(2+)-activated chloride currents were studied in cultured neurones from rat dorsal root ganglia. 2. Palmitoyl-DL-carnitine applied to the
Sexual dimorphism in myocardial acylcarnitine and triglyceride metabolism
Devanathan S, et al.
Biology of sex differences, 7(1), 25-25 (2016)
N Inoue et al.
Cardiovascular research, 28(1), 129-134 (1994-01-01)
Palmitoyl-L-carnitine, which accumulates in ischaemic myocardium, may influence the function of vascular endothelium in the ischaemic area. The aim of the study was therefore to examine the effect of palmitoyl-L-carnitine on endothelium dependent relaxations of rabbit thoracic aortas and its
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