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P0099

Sigma-Aldrich

帕潘立酮

≥98% (HPLC)

别名:

3-[2-[4-（6-氟-1,2-苯并异恶唑-3-基）-1-哌啶基] 乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并 [1,2-a] 嘧啶-4-酮, 9-羟基利培酮

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About This Item

经验公式（希尔记法）:
C23H27FN4O3
CAS号:
144598-75-4
分子量:
426.48
MDL號碼:
MFCD00871802
分類程式碼代碼:
12352200
PubChem物質ID:
329820012
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to brown

溶解度

DMSO: 2 mg/mL, clear (warmed)

起源

Johnson & Johnson

儲存溫度

room temp

SMILES 字串

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI 密鑰

PMXMIIMHBWHSKN-UHFFFAOYSA-N

基因資訊

human ... DRD2(1813) , HTR2A(3356)

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相关类别

應用

帕潘立酮已被用作非典型抗精神病药（AAPD），用于研究其预防脂多糖（LPS）激发的产前免疫小鼠精神疾病的功效。它还被用作非典型抗精神病药（AAPD），用于诠释以细菌内毒素脂多糖（LPS）处理的雌性产前小鼠中下丘脑-垂体-肾上腺（HPA）轴的调节。

生化／生理作用

帕利哌酮属于非典型抗精神病药；利培酮的活性代谢产物。

特點和優勢

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 强生开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
045M4709V
099K4713
038K47152
038K47151
038K4715

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