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O1141

Sigma-Aldrich

奥氮平

≥98% (HPLC)

别名:

2-甲基-4-（4-甲基-1-哌嗪基）-10H-噻吩并[2,3-b] [1,5]苯并二氮杂

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About This Item

经验公式（希尔记法）:
C17H20N4S
CAS号:
132539-06-1
分子量:
312.43
Beilstein:
7655141
MDL號碼:
MFCD00866702
分類程式碼代碼:
12352200
PubChem物質ID:
329818894
NACRES:
NA.77

品質等級

100

化驗

≥98% (HPLC)

形狀

powder

顏色

yellow

溶解度

DMSO: >15 mg/mL

起源

Eli Lilly

儲存溫度

2-8°C

SMILES 字串

CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24

InChI

1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,19H,7-10H2,1-2H3

InChI 密鑰

KVWDHTXUZHCGIO-UHFFFAOYSA-N

基因資訊

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

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生化／生理作用

Olanzapine is a 5-HT2 serotonin and D1/D2 dopamine receptor antagonist.

特點和優勢

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險分類

Acute Tox. 3 Oral - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

標靶器官

Central nervous system

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
035M4781V
063M4753V
063M4727V
072M4720V
021M4703V

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W Wolfgang Fleischhacker et al.
Biological psychiatry, 65(6), 510-517 (2008-11-07)
Few studies have directly compared the efficacy and tolerability of atypical agents. This multicenter, randomized, double-blind study compared the efficacy and tolerability of aripiprazole (n = 355) with olanzapine (n = 348) in patients with schizophrenia experiencing acute relapse. After
N A Moore et al.
The Journal of pharmacology and experimental therapeutics, 262(2), 545-551 (1992-08-01)
Olanzapine (LY170053, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine) is a novel "atypical" antipsychotic agent with 5-hydroxytryptamine2.dopamine D1/D2 antagonist activity and anticholinergic properties. In behavioral studies, olanzapine (1.25-10 mg/kg, p.o.) antagonizes apomorphine-induced climbing behavior in mice, demonstrating that the compound possesses D1/D2 antagonist activity in
Joseph P McEvoy et al.
The Journal of clinical psychiatry, 74(2), 170-179 (2013-03-12)
To examine the effectiveness of switching patients to lurasidone using 3 different dosing strategies. Adults with DSM-IV-defined schizophrenia or schizoaffective disorder in a nonacute phase of illness were randomized to 1 of 3 lurasidone dosing regimens for the initial 2
Mao M Söderberg et al.
Pharmacogenetics and genomics, 23(5), 279-285 (2013-03-16)
Metabolism of the atypical antipsychotic olanzapine (OLA) is partially catalyzed by cytochrome P450 (CYP) 1A2, a target of aryl hydrocarbon receptor (AHR)-mediated induction. We investigated the influence of four cis-acting polymorphisms (rs2470893C>T and rs2472297C>T between CYP1A1 and CYP1A2 loci, and
Heating under high-frequency inductive conditions: application to the continuous synthesis of the neurolepticum olanzapine (Zyprexa).
Jan Hartwig et al.
Angewandte Chemie (International ed. in English), 52(37), 9813-9817 (2013-07-31)
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