推荐产品
product name
NGF-β human, from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in NSO cells
化驗
>97% (SDS-PAGE)
形狀
lyophilized powder
效力
0.15-3.0 ng/mL ED50/EC50
品質
endotoxin tested
包裝
pkg of 5X0.1 mg
pkg of 0.1 mg
技術
cell culture | mammalian: suitable
雜質
<1 EU/μg
溶解度
water: soluble 0.1 g/L at 20 °C
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... NGF(4803)
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一般說明
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.
應用
NGF-β human has been used:
- in protein pin arrays
- to induce U87-MG (glioblastoma cell line) cell proliferation
- in drug release kinetics
生化／生理作用
Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.
外觀
Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.
分析報告
The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
K A Crutcher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(6), 2540-2550 (1993-06-01)
A two-site ELISA and a bioassay were used to detect NGF-like activity in human brain tissue. Both assays detected mouse NGF and recombinant human NGF with approximately equal sensitivity, whereas the antibodies showed little cross-reactivity with the recombinant human proteins
Nerve Growth Factor Stimulates Glioblastoma Proliferation through Notch1 Receptor Signaling
Park JC, et al.
Journal of Korean Neurosurgical Society, 61(4), 441-441 (2018)
Mahmoud Aarabi et al.
Fertility and sterility, 102(2), 440-447 (2014-06-09)
To determine the levels of postacrosomal WW binding protein (PAWP) in the spermatozoa of men that were used clinically for intracytoplasmic sperm injection (ICSI) and to correlate them with infertility treatment outcomes. Prospective clinical and laboratory study. University-based laboratory and
S Korsching
The Journal of neuroscience : the official journal of the Society for Neuroscience, 13(7), 2739-2748 (1993-07-01)
The neurotrophic factor concept in its basic form envisages that innervated tissues produce a signal for the innervating neurons for the selective limitation of neuronal death occurring during development (Purves, 1986; Oppenheim, 1991). This concept arose several decades ago on
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski MH, et al.
Nature Medicine, 11(5), 551-551 (2005)
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