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生物源
mouse
重組細胞
expressed in E. coli
化驗
≥97% (HPLC)
≥97% (SDS-PAGE)
形狀
lyophilized
分子量
13.6 kDa
包裝
pkg of 10 μg
雜質
Endotoxin, tested
NCBI登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... NTF3(18205)
一般說明
NT-3 (neurotrophin-3) is a member of the family of trophic factors, called neurotrophins. This family also includes NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), and NT-4. NT-3 is the most abundantly expressed neurotrophin during early development.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
Murine NT-3 produced from Escherichia coli contains 119 amino acid and having a molecular mass is 13.6kDa.
應用
NT-3 (neurotrophin-3) has been used for the ex vivo treatment of skin punches obtained from rat and human samples.
生化／生理作用
Study in mice show that NT-3 (neurotrophin-3), along with BDNF (brain-derived neurotrohpic factor), is essential for inner ear development. In vitro motor, enteric, primary sensory, sympathetic, locus coeruleus, cerebellar and hippocampal neurons are responsive to NT-3. Mice null for NT-3 show significant deficiency in sympathetic and sensory nerve populations. In mice, post birth up-regulation of NT-3 induces a second wave of dopaminergic amacrine cell genesis.
外觀
Sterile filtered and lyophilized powder
重構
Centrifuge the vial prior to opening. Reconstitute in H?O to a concentration of 0.1-1.0 mg/ml.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway.
Price EA et al
Journal of Neuroscience Methods, 282, 34-42 (2017)
Complementary roles of BDNF and NT-3 in vestibular and auditory development.
Ernfors P et al
Neuron, 14(6), 1153-1164 (1995)
Overexpression of neurotrophin-3 stimulates a second wave of dopaminergic amacrine cell genesis after birth in the mouse retina.
Yoshida M et al
The Journal of Neuroscience, 31(35), 12663-12673 (2011)
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3.
Fari?as I et al
Nature, 369(6482), 658-661 (1994)
Shyan-Yuan Kao et al.
Bone, 145, 115837-115837 (2021-01-02)
The bone encasing the inner ear, known as the otic capsule, is unique because it remodels little postnatally compared to other bones in the body. Previous studies established that osteoprotegerin (OPG) in the inner ear inhibits otic capsule remodeling. OPG
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