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Merck
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M9656

Sigma-Aldrich

H-8 dihydrochloride

>98% (HPLC)

别名:

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

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About This Item

经验公式（希尔记法）:
C12H15N3O2S · 2HCl
CAS号:
113276-94-1
分子量:
338.25
MDL號碼:
MFCD00036962
分類程式碼代碼:
12352200
PubChem物質ID:
24278039
NACRES:
NA.77

化驗

>98% (HPLC)

形狀

powder

儲存溫度

2-8°C

SMILES 字串

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI 密鑰

RJJLZYZEVNCZIW-UHFFFAOYSA-N

基因資訊

human ... CALCRL(10203) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)
rat ... Calcrl(25029)

生化／生理作用

cAMP and cGMP-dependent protein kinase inhibitor.

特點和優勢

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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F Shirakawa et al.
Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)
We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110766-110766 (2020-11-07)
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment
H Hidaka et al.
Biochemistry, 23(21), 5036-5041 (1984-10-09)
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

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