所有图片(2)
About This Item
经验公式（希尔记法）:
C9H5N3O2
CAS号:
分子量:
187.15
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.32
推荐产品
化驗
≥98% (TLC)
品質等級
形狀
powder
顏色
pale yellow
溶解度
ethanol: 1.2 mg/mL
DMSO: 5 mg/mL
H2O: insoluble
儲存溫度
2-8°C
SMILES 字串
O=C1ON=C2C=Nc3ccccc3N12
InChI
1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChI 密鑰
LZMHWZHOZLVYDL-UHFFFAOYSA-N
基因資訊
human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
應用
1H-[1,2,4]恶二唑[4,3-a]喹喔啉-1-酮已被用作亲和选择质谱 (AS-MS) 化合物结合检测中的氧化剂 作为可溶性鸟苷酸环化酶 (sGC) 抑制剂用于抑制S-亚硝基-N-乙酰基-DL-青霉胺 (SNAP) 诱导的cGMP生产。
生化／生理作用
H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮（ODQ）能够非竞争性地抑制一氧化氮敏感性鸟苷酸环化酶的作用，并且可能导致血红素辅基发生不可逆氧化。 ODQ已被用于研究环磷酸鸟苷（cGMP）途径在一氧化氮（NO）信号转导中的作用。
一氧化氮敏感性鸟苷酸环化酶的选择性抑制剂。
注意
吸湿
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Lineu Baldissera et al.
Pulmonary pharmacology & therapeutics, 41, 86-95 (2016-11-07)
Activators of soluble guanylyl cyclase (sGC) act preferentially in conditions of enzyme oxidation or haem group removal. This study was designed to investigate the effects of the sGC activator BAY 60-2770 in murine airways inflammation and human eosinophil chemotaxis. C57Bl/6
Diana Braun et al.
Frontiers in physiology, 9, 480-480 (2018-05-19)
Ischemia/reperfusion injury holds a key position in many pathological conditions such as acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized that besides a reported disproportional activation of vasoconstrictor response, hypoxia/reoxygenation (H/R) adversely affects
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
Schrammel A
Molecular Pharmacology, 50(1), 1-5 (1996)
J Garthwaite et al.
Molecular pharmacology, 48(2), 184-188 (1995-08-01)
In brain and other tissues, nitric oxide (NO) operates as a diffusible second messenger that stimulates the soluble form of the guanylyl cylase enzyme and so elicits an accumulation of cGMP in target cells. Inhibitors of NO synthesis have been
Serena Materazzi et al.
Microvascular research, 109, 38-44 (2016-11-08)
The role of endogenous H2S has been highlighted as a gaseous transmitter. The vascular smooth muscle inhibitory effects of H2S have been characterized in isolated aorta and mesenteric arteries in rats and mice. Our study was aimed at investigating the
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