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Merck

M2518

Sigma-Aldrich

亚硫酸氢钠甲萘醌

BioReagent, suitable for cell culture, ≥95% (TLC)

别名:

2-甲基-1,4-萘醌亚硫酸氢钠

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About This Item

经验公式(希尔记法):
C11H9NaO5S
CAS号:
分子量:
276.24
EC號碼:
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.75

生物源

synthetic (organic)

品質等級

產品線

BioReagent

化驗

≥95% (TLC)

形狀

powder

分子量

Mw 276.24 g/mol

技術

cell culture | mammalian: suitable
cell culture | plant: suitable

顏色

white to off-white

溶解度

water: soluble 50 mg/mL, clear, colorless to light yellow

儲存溫度

−20°C

SMILES 字串

[Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O

InChI

1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1

InChI 密鑰

XDPFHGWVCTXHDX-UHFFFAOYSA-M

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應用

亚硫酸氢钠甲萘醌已用于:
  • 研究其作为自由基诱导剂对向日葵幼苗氧化应激反应的影响
  • 在人肾近曲小管上皮细胞系O2含量测定中作为阳性对照,刺激线粒体产生O2
  • 作为线粒体氧化还原循环促氧化剂,研究其对心肌细胞中蛋白激酶B(AKT)和雷帕霉素机能靶蛋白(mTOR)信号传导的影响作用

生化/生理作用

亚硫酸氢钠甲萘醌(MSB)是一种维生素K3衍生物,经研究可治疗维生素K3缺乏引起的出血性疾病,包括低凝血酶原血症和新生儿出血。还可用作动物的营养补充剂。MSB具有抗癌作用。还可保护植物抵抗生物和非生物胁迫。

其他說明

水溶性维生素 K3

免責聲明

本品不可用作全球生物杀灭剂法规监管的生物杀灭剂,包括但不限于:美国联邦杀虫剂、杀菌剂和灭鼠剂法(US EPA′s Federal Insecticide Fungicide and Rodenticide Act)、欧盟生物杀灭剂法规(European Biocidal Products Regulation)、加拿大虫害管理监管机构(Canada’s Pest Management Regulatory Agency)、土耳其生物杀灭剂法规(Turkey’s Biocidal Products Regulation)、韩国生物杀灭剂法(Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR))等。

象形圖

Exclamation markEnvironment

訊號詞

Warning

危險聲明

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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Y Sanada et al.
Free radical research, 48(8), 919-928 (2014-05-29)
Human oxidation resistance 1 (OXR1) functions in protection against oxidative damage and its homologs are highly conserved in eukaryotes examined so far, but its function still remains uncertain. In this study, we identified a homolog (LMD-3) of human OXR1 in
Kenneth W Olsen et al.
Molecular vision, 17, 270-278 (2011-02-02)
The crystalline lens is a unique cellular organ that performs metabolic processes while maintaining transparency for optical functionality. Mitochondria play a role in providing cells with aerobic respiration necessary for these metabolic processes. Using menadione, a mitochondria-specific inhibitor of the
Dmytro V Gospodaryov et al.
Biochimica et biophysica acta, 1837(11), 1861-1869 (2014-08-16)
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased
Irina Baran et al.
Cell biochemistry and biophysics, 58(3), 169-179 (2010-08-11)
Menadione (MD) is an effective cytotoxic drug able to produce intracellularly large amounts of superoxide anion. Quercetin (QC), a widely distributed bioflavonoid, can exert both antioxidant and pro-oxidant effects and is known to specifically inhibit cell proliferation and induce apoptosis
Tomokazu Souma et al.
Journal of the American Society of Nephrology : JASN, 22(4), 635-648 (2011-03-05)
A highly acidic environment surrounds proximal tubular cells as a result of their reabsorption of HCO(3)(-). It is unclear whether this luminal acidity affects proteinuria-induced progression of tubular cell damage. Here, we investigated the contribution of luminal acidity to superoxide

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