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Key Documents

K2628

Sigma-Aldrich

酮替芬 富马酸盐

≥99% (TLC), powder, H₁ histamine receptor antagonist

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About This Item

经验公式（希尔记法）:
C19H19NOS · C4H4O4
CAS号:
34580-14-8
分子量:
425.50
EC號碼:
252-100-0
MDL號碼:
MFCD00079394
分類程式碼代碼:
12352200
PubChem物質ID:
24278506
NACRES:
NA.77

product name

酮替芬 富马酸盐,

形狀

powder

品質等級

100

起源

Novartis

SMILES 字串

OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24

InChI

1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChI 密鑰

YNQQEYBLVYAWNX-WLHGVMLRSA-N

基因資訊

human ... HRH1(3269) , PDE7B(27115)

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一般說明

富马酸酮替芬盐是一种抗组胺药。

應用

富马酸酮替芬盐已被用于：肥大细胞产物拮抗作用，作为 β-氨基己糖苷酶释放测试的阳性对照，作为肥大细胞稳定剂添加到饮用水中用于治疗怀孕母兽

生化／生理作用

H1 组胺受体拮抗剂。
富马酸酮替芬通过阻断组胺H1受体而在阻止组胺的释放中起关键作用。它会干扰肥大细胞释放组胺、血清素和其他炎症介质。它具有抗过敏活性、消炎作用（包括使肥大细胞稳定）。它已被广泛用于眼部过敏性结膜炎。

特點和優勢

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302,H319

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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