推荐产品
product name
(S)-(+)-美芬妥英, solid, ≥98% (HPLC)
化驗
≥98% (HPLC)
形狀
solid
顏色
off-white
mp
135-138 °C
溶解度
DMSO: soluble
儲存溫度
2-8°C
SMILES 字串
CC[C@]1(NC(=O)N(C)C1=O)c2ccccc2
InChI
1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)/t12-/m0/s1
InChI 密鑰
GMHKMTDVRCWUDX-LBPRGKRZSA-N
應用
S-美芬妥因已被用作 CYP2C19 底物，用于分析细胞色素 P450 代谢。S-美芬妥因也被用作基于 LC/MS 的相对活性因子（RAF）分析的探针底物。
生化／生理作用
CYP2B6 & CYP2C19 底物。Methenytoin 异构体。镇惊；抗癫痫。
特點和優勢
这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
包裝
无底玻璃瓶。内含物装在插入的融合锥内。
準備報告
（S）-（+）-美芬妥因可溶于 DMSO。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Brandon S Pybus et al.
Malaria journal, 11, 259-259 (2012-08-04)
The 8-aminoquinoline (8AQ) drug primaquine (PQ) is currently the only approved drug effective against the persistent liver stage of the hypnozoite forming strains Plasmodium vivax and Plasmodium ovale as well as Stage V gametocytes of Plasmodium falciparum. To date, several
Stefan J Dekker et al.
British journal of pharmacology, 176(3), 466-477 (2018-11-18)
The aim of this study was to characterize the human cytochrome P450s (CYPs) involved in oxidative bioactivation of flucloxacillin to 5-hydroxymethyl flucloxacillin, a metabolite with high cytotoxicity towards biliary epithelial cells. The CYPs involved in hydroxylation of flucloxacillin were characterized
Bent H Hellum et al.
Basic & clinical pharmacology & toxicology, 105(1), 58-63 (2009-04-18)
The aim of this study was to evaluate in vitro the dose-dependent induction potential of six commonly used trade herbal products on CYP2C19 and CYP2E1 metabolic activities in cultured human hepatocytes. S-mephenytoin and chlorzoxazone were used as specific CYP substrates
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