I7016

H-7 dihydrochloride

≥98% (HPLC)

• 别名: 1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride, Isoquinoline-5-sulfonic 2-methyl-1-piperazide dihydrochloride
• 经验公式（希尔记法）: C₁₄H₁₇N₃O₂S · 2HCl
• CAS号: 108930-17-2
• 分子量: 364.29
• Beilstein: 5840763
• MDL號碼: MFCD00036961
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278496
• NACRES: NA.77

属性

• 化驗: ≥98% (HPLC)
• 形狀: powder
• 溶解度: H₂O: 20 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: Cl.Cl.CC1CNCCN1S(=O)(=O)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c1-11-9-16-7-8-17(11)20(18,19)14-4-2-3-12-10-15-6-5-13(12)14;;/h2-6,10-11,16H,7-9H2,1H3;2*1H
• InChI 密鑰: OARGPFMFRLLKPF-UHFFFAOYSA-N
• 基因資訊: human ... PRKCA(5578) , PRKCB(5579) , PRKCD(5580) , PRKCE(5581) , PRKCG(5582) , PRKCH(5583) , PRKCI(5584)

说明

一般說明

H-7 dihydrochloride blocks human immunodeficiency virus (HIV-1) replication in MOLT-4 (clone No. 8) cell line. It increases the secretion of interleukin 1β (IL-1β).

應用

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

生化／生理作用

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

注意

Light sensitive

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)