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Merck
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文件

H3884

Sigma-Aldrich

透明质酸酶 来源于牛睾丸

Type IV-S, lyophilized powder (essentially salt-free), 750-3000 units/mg solid

别名:

玻璃糖醛酸酶, 玻璃酸酶

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About This Item

CAS号:
37326-33-3
EC 号:
3.2.1.35 (BRENDA, IUBMB)
EC號碼:
253-464-3
MDL號碼:
MFCD00131351
分類程式碼代碼:
12352204

生物源

bovine testis

品質等級

200

共軛

conjugate (Glucosaminoglycan)

種類

Type IV-S

形狀

lyophilized powder (essentially salt-free)

比活性

750-3000 units/mg solid

分子量

~55 kDa (four subunits of 14 kDa each)

UniProt登錄號

Q5E985
Q8SQG8

應用

diagnostic assay manufacturing

相關疾病

cancer

儲存溫度

−20°C

基因資訊

cow ... HYAL1(515397) , HYAL2(281838)

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相关类别

生化／生理作用

这些酶可随机裂解透明质酸、软骨素和硫酸软骨素中的 β-N-乙酰己糖胺-[1→4] 糖苷键。
透明质酸酶可降解透明质酸，并已发现可在癌症进展期间会被不适当地调节。

單位定義

在 37 ºC、pH 5.35 条件下，一单位每分钟可降解 0.75 μg 多糖透明质酸（通过比浊吸光度测量(λ: 600nm)，与 BSA 复合 45 分钟后测量）。

其他說明

有关复合碳水化合物分析酶的更多信息，请见www.sigma-aldrich.com/enzymeexplorer

象形圖

Health hazard
GHS08

訊號詞

Danger

危險聲明

H334

防範說明

P261 - P284 - P501

危險分類

Resp. Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Claire M McLeod et al.
Scientific reports, 6, 38852-38852 (2016-12-13)
Extracellular matrix dynamics are key to tissue morphogenesis, homeostasis, injury, and repair. The spatiotemporal organization of this matrix has profound biological implications, but is challenging to monitor using standard techniques. Here, we address these challenges by using noncanonical amino acid
Matthew R Kent et al.
Neural regeneration research, 16(2), 367-374 (2020-08-30)
A potential treatment for retinal diseases is to induce an endogenous Müller glia (MG)-derived regenerative response to replace damaged neurons. In contrast to mammalian MG, zebrafish MG are capable of mediating spontaneous regeneration. We seek to define the mechanisms that
Alicia Santos Savio et al.
BMC musculoskeletal disorders, 16, 51-51 (2015-04-17)
Pro-inflammatory cytokines are directly implicated in the pathogenesis of Rheumatoid arthritis (RA). Variable clinical response to cytokine targeted therapies as TNFalpha and IL-6, strongly highlights the heterogeneity of inflammatory process in RA. Another cytokine, IL-15 has also been related to
Carlos Henríquez-Olguín et al.
Redox biology, 24, 101188-101188 (2019-04-09)
Reactive oxygen species (ROS) have been proposed as signaling molecules mediating exercise training adaptation, but the ROS source has remained unclear. This study aimed to investigate if increased NADPH oxidase (NOX)2-dependent activity during exercise is required for long-term high-intensity interval
Isabel N Tromp et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 39(9), 1955-1964 (2020-11-23)
It has been suggested that curvature progression in adolescent idiopathic scoliosis occurs through irreversible changes in the intervertebral discs. Strains of mice have been identified who differ in their disc wedging response upon extended asymmetrical compression. Annulus fibrosus (AF) tissue
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