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包裝
pack of 2500 U
製造商／商標名
Cytiva E70073Z
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
Exonuclease I.
The EXO1 (exonuclease I) gene is mapped to human chromosome 1q43 and codes for a 5′→3′ exonuclease of 846 amino acids. It belongs to the 5′-nuclease superfamily.
應用
Acts specifically on single-stranded DNA degrading it processively in the 3′- to 5′-direction, producing 5′-mononucleotides.
生化／生理作用
Exonuclease I (EXO1) maintains genomic stability by participating in DNA mismatch repair system, DNA recombination, DNA replication and DNA double-stranded break repair in eukaryotes. It also modulates meiosis, immunoglobulin maturation, and micro-mediated end-joining. It functions on DNA with blunt, nicked, gapped and 3′-overhangs. It also possesses endonuclease action and removes 5′-single-stranded flaps that protrudes from a double stranded DNA. Mutation in EXO1 gene results in increased susceptibility to develop cancer.
特點和優勢
- Eliminating residual single-stranded DNA containing a 3′-terminus.
- Measuring endonucleolytic cleavage of covalently closed circular (ccc) ssDNA.
- Measuring DNA helicase activity.
儲存和穩定性
Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.
分析報告
To view the Certificate of Analysis for this product, please visit www.cytiva.com.
儲存類別代碼
12 - Non Combustible Liquids
其他客户在看
Human Exonuclease 1 Threads 5?-Flap Substrates through Its Helical Arch.
Shaw S J, et al.
Biochemistry, 56(29), 3704-3707 (2017)
Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma.
Tan S, et al.
Oncotarget, 7(52), 87180-87180 (2016)
Exonuclease 1 and its versatile roles in DNA repair.
Keijzers G, et al.
Critical Reviews in Biochemistry and Molecular Biology, 51(6), 440-451 (2016)
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