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品質等級
化驗
≥97% (HPLC)
形狀
powder
分子量
437.55
儲存條件
(Keep container tightly closed in a dry and well-ventilated place)
技術
activity assay: suitable
溶解度
acetic acid: 20 mg/mL, clear, colorless
儲存溫度
−20°C
SMILES 字串
CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
InChI
1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChI 密鑰
PRQROPMIIGLWRP-BZSNNMDCSA-N
基因資訊
human ... FPR1(2357)
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Amino Acid Sequence
NFor-Met-Leu-Phe
一般說明
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸是（N-Formyl-Met-Leu-Phe, fMLP）一种趋化因子肽，可作用于多形核白细胞（PMN）、中性粒细胞等
研究领域：细胞信号传导
研究领域：细胞信号传导
應用
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸已用于：
- 中性粒细胞Zigmond室法趋化分析中的梯度构建
- 中性粒细胞趋化测定
- 确定MAPK活化蛋白激酶-2（MAPKAPK-2）和/或p38是否参与由N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸刺激的人多形核白细胞（PMN）的信号传导途径。
生化／生理作用
N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸可诱导磷酸肌醇3-激酶γ（PI3K）γ-/- 中性粒细胞的趋化、促进F-肌动蛋白的粘附和聚合，以及Fcγ受体介导的吞噬作用和细胞内Ca2+ 的释放。它可作为炎症因子，激活多形核白细胞（PMNs），且不会产生5-羟基山梨酸（5-HETE）和白三烯B4 （LTB4）。其对中性粒细胞的影响，以及腺苷酸环化酶的抑制效果可被百日咳毒素所抑制。
有效的趋化肽。诱导巨噬细胞的代谢爆发，并伴随着呼吸速率的增加、溶酶体酶的分泌以及超氧阴离子的产生。
白细胞趋化的强效诱导剂和巨噬细胞的激活剂。 研究发现结合甲酰基肽的受体存在于吞噬性中性粒细胞上，并且最近已在肠粘膜细胞上发现。
抗體
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
P M Lad et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(3), 869-873 (1985-02-01)
Pertussis toxin inhibits the N-formyl-Met-Leu-Phe (fMet-Leu-Phe) mediated human neutrophil functions of enzyme release, superoxide generation, aggregation, and chemotaxis. As pertussis toxin modifies the GTP binding receptor-regulatory protein "Ni," the association of the fMet-Leu-Phe receptor with such a protein was further
Carlos José Correia Santana et al.
Biomolecules, 10(5) (2020-05-24)
In recent years, the number of new antimicrobial drugs launched on the market has decreased considerably even though there has been an increase in the number of resistant microbial strains. Thus, antimicrobial resistance has become a serious public health problem.
R M Clancy et al.
Proceedings of the National Academy of Sciences of the United States of America, 80(23), 7200-7204 (1983-12-01)
Release of arachidonic acid by the membrane phospholipase and metabolism by the 5-lipoxygenase pathway was examined in human polymorphonuclear leukocytes (PMNs). The 5-lipoxygenase pathway is activated when PMNs are given arachidonic acid in ethanol and there is extensive metabolism to
Ildefonso M De la Fuente et al.
Nature communications, 10(1), 3690-3690 (2019-08-17)
Associative memory is the main type of learning by which complex organisms endowed with evolved nervous systems respond efficiently to certain environmental stimuli. It has been found in different multicellular species, from cephalopods to humans, but never in individual cells.
E Krump et al.
The Journal of biological chemistry, 272(2), 937-944 (1997-01-10)
Activation of polymorphonuclear leukocytes (PMN) by chemotactic peptides initiates a series of functional responses that serve to eliminate pathogens. The intermediate steps that link engagement of the chemoattractant receptor to the microbicidal responses involve protein kinases that have yet to
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