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Merck
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主要文件

SML1575

Sigma-Aldrich

环孢菌素H

≥97% (HPLC)

别名:

1,4,7,10,13,16,19,22,25,28,31-十一碳氮杂环三金刚烷，环肽衍生物, 5-（N-甲基-D-缬氨酸）-环孢菌素A

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About This Item

经验公式（希尔记法）:
C62H111N11O12
CAS号:
83602-39-5
分子量:
1202.61
分類程式碼代碼:
51111800
NACRES:
NA.77

生物源

Tolypocladium inflatum

品質等級

100

化驗

≥97% (HPLC)

形狀

powder

光學活性

[α]/D -100 to -115°, c = 0.5 in methanol

儲存條件

desiccated
protect from light

顏色

white to beige

儲存溫度

−20°C

InChI

1S/C63H113N11O12/c1-26-28-29-41(15)53(76)52-56(79)66-44(27-2)58(81)67(18)34-49(75)68(19)46(31-36(5)6)60(83)72(23)50(39(11)12)62(85)69(20)45(30-35(3)4)55(78)64-42(16)54(77)65-43(17)57(80)70(21)47(32-37(7)8)59(82)71(22)48(33-38(9)10)61(84)73(24)51(40(13)14)63(86)74(52)25/h26,28,35-48,50-53,76H,27,29-34H2,1-25H3,(H,64,78)(H,65,77)(H,66,79)/b28-26+/t41-,42+,43-,44+,45+,46+,47+,48+,50-,51+,52?,53-/m1/s1

InChI 密鑰

BQQHPBPTWWXRMU-SXHXJWHLSA-N

應用

环孢素H已被用于：
  • 预培养用于转导的谱系缺失的小鼠 Flt3ITDIDH2R140Q BM 细胞
  • 作为甲酰肽受体（FPR）拮抗剂来研究FPR1在多形核白细胞（PMN）钙动员中的作用
  • 作为研究其对人类诱导多能干细胞（iPSC）和 T 细胞同源定向修复（HDR）编辑效率影响的小分子之一

生化／生理作用

环孢菌素 H 是中性粒细胞中甲酰肽受体 1（FPR-1）和甲酰肽诱导的超氧化物形成的选择性抑制剂。 环孢菌素 H 不结合亲环蛋白或引起免疫抑制反应。 据报道，环孢菌素 H 抑制小鼠皮肤细胞中促进肿瘤的佛波酯 TPA/PMA，并抑制钙/钙调蛋白依赖性的 EF-2 磷酸化。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Danger

危險聲明

H302,H350,H360

危險分類

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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