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F0287

Sigma-Aldrich

来自人血浆的纤连蛋白蛋白水解片段

lyophilized powder, 70 kDa

别名:

纤连蛋白 溶液 来源于人类成纤维细胞

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About This Item

MDL號碼:
MFCD00131062
分類程式碼代碼:
12352202
eCl@ss:
42020141
NACRES:
NA.75

生物源

human plasma

品質等級

200

化驗

>90% (SDS-PAGE)

形狀

lyophilized powder

分子量

70 kDa

包裝

pkg of 0.5 mg

技術

cell culture | mammalian: suitable

雜質

HIV and HBsAg, source material tested negative
 Small proteolytic fragments, may contain traces

溶解度

water: soluble ≥0.500 mg/mL, clear to slightly hazy, colorless

UniProt登錄號

P02751

運輸包裝

ambient

儲存溫度

−20°C

基因資訊

human ... FN1(2335)

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相关类别

一般說明

Fibronectin 1 is a glycoprotein of the extracellular matrix that is coded by FN1 gene. It is expressed in the plasma and at the cell surface. FN1 is mapped to human chromosome 2q35. Proteolytic fragments of fibronectin has a cell binding domain.

應用

Fibronectin Proteolytic Fragment from human plasma has been used in pre adsorbed antibody blocking assay and EC-pericyte tube coassembly.

生化／生理作用

Fibronectin participates in cell adhesion, growth, migration, wound healing, blood coagulation and metastasis. Mutations in FN1 results in glomerulopathy. It plays an important role in cell attachment and spreading, control of cell cytoskeleton, morphology and differentiation. FN1 is also involved in extracellular matrix formation, hemostasis and thrombosis. Proteolytic fragments of fibronectin plays a vital role in mononuclear phagocyte function.

注意

The product should be stored at -20°C.

準備報告

This product is lyophilized from phosphate buffered saline with sucrose as a cryoprotectant. The source material has tested negative for antibody to HIV, HCN, and HBsAg. It is soluble in water at 0.5 mg/mL and yields a clear to slightly hazy solution.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Ail protein binds ninth type III fibronectin repeat (9FNIII) within central 120 kDa region of fibronectin to facilitate cell binding by Yersinia pestis.
Tsang T M, et al.
The Journal of Biological Chemistry, 287(20), 16759-16767 (2012)
Fibronectin in Health and Disease (2018)
C Penn et al.
Microbial pathogenesis, 17(6), 387-393 (1994-12-01)
Candida albicans yeast cells bind soluble human plasma fibronectin (Fn) through a glycoprotein receptor (adhesin) located on the cell surface. This work demonstrates that a 120 kDa proteolytic fragment of Fn encompassing the cell binding domain binds more avidly to
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation.
Stratman A N, et al.
Blood, 114(24), 5091-5101 (2009)
Silke Niemann et al.
mBio, 12(5), e0106221-e0106221 (2021-10-20)
While Staphylococcus aureus has classically been considered an extracellular pathogen, these bacteria are also capable of being taken up by host cells, including nonprofessional phagocytes such as endothelial cells, epithelial cells, or osteoblasts. The intracellular S. aureus lifestyle contributes to
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商品

Extracellular Matrix Proteins and Tools for Cell Culture Optimization

Extracellular matrix proteins such as laminin, collagen, and fibronectin can be used as cell attachment substrates in cell culture.

实验方案

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs at sigmaaldrich.com

Fibronectin Coating Protocol

Dilute fibronectin to the desired concentration. Optimum conditions for attachment are dependent on cell type and application. The typical coating concentration is 1 – 5 ug/cm2.Fibronectin coating protocol, products, and FAQs.

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