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一般說明
羧酸酯酶1（CE1）是大型多基因羧酸酯酶 α,β水解酶家族的成员。它主要在肝脏中表达。CE1 包括一个 αβ 结构域、一个中心催化结构域和一个调控结构域。
應用
人羧酸酯酶 1 亚型 c 已被用作贻贝羧酸酯酶活性的参考标准，用于比较底物特异性和抑制研究。它还被用作商业重组蛋白，用于基于环境化学的抑制研究的方法验证。
生化／生理作用
羧酸酯酶负责水解含有酯键和酰胺键的药物，例如可卡因和海洛因。它们还水解长链脂肪酸酯和硫酯。羧酸酯酶 1（CE1）催化胆固醇和脂肪酸形成胆固醇酯。通过酯交换反应，CE1 还介导脂肪酸乙酯（FAEE）的产生。它还水解芳族和脂族酯，优先于小的醇基和大的酰基。CE1 代谢药物酯类和酰胺类氨基甲酸酯。它参与环境毒物和致癌物的解毒，并可用于评估前药的药代动力学研究。
物理性質
该产品的体积为0.5 mL。
單位定義
一个单位是指在pH 7.4、37℃下，每分钟水解1纳摩尔4-硝基苯基乙酸酯所需的酶量
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Montserrat Solé et al.
Environmental toxicology and pharmacology, 82, 103561-103561 (2020-12-12)
Carboxylesterases (CEs) are key enzymes which catalyse the hydrolysis reactions of multiple xenobiotics and endogenous ester moieties. Given their growing interest in the context of marine pollution and biomonitoring, this study focused on the in vitro sensitivity of marine invertebrate
Jihong Lian et al.
Protein & cell, 9(2), 178-195 (2017-07-06)
Mammalian carboxylesterases hydrolyze a wide range of xenobiotic and endogenous compounds, including lipid esters. Physiological functions of carboxylesterases in lipid metabolism and energy homeostasis in vivo have been demonstrated by genetic manipulations and chemical inhibition in mice, and in vitro
Masakiyo Hosokawa
Molecules (Basel, Switzerland), 13(2), 412-431 (2008-02-29)
Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an alpha,beta-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can
Dandan Wang et al.
Acta pharmaceutica Sinica. B, 8(5), 699-712 (2018-09-25)
Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism
B Sànchez-Nogué et al.
Environmental science and pollution research international, 20(5), 3480-3488 (2012-12-06)
The common sole, Solea solea (Linneus, 1758), and the Senegalese sole, Solea senegalensis (Kaup, 1858), are two important commercial species that coexist in the NW Mediterranean. In order to assess the species' ability to respond to chemical insults, a comparison
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