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重組細胞
expressed in mouse NSO cells
品質等級
化驗
≥95% (SDS-PAGE)
形狀
solution
比活性
≥1.0 EU/μg
30,000 pmol/min-μg protein
分子量
predicted mol wt ~60 kDa
濃度
0.4-0.6 mg/mL
雜質
≤1.0 EU/μg endotoxin
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... CES2(8824)
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生化／生理作用
人羧酸酯酶2（hCE-2）可识别具有大醇基和小酰基的底物。由于在活性位点口袋中存在构象干扰，其底物特异性可能受到酰基-hCE-2缀合物形成能力的限制。羧基酯酶可催化几种含酯的药物和前药的生物转化，例如血管紧张素转化酶抑制剂（替莫卡普、西拉普利）、抗肿瘤药（卡培他滨）和麻醉药。
可水解酯和酰胺键的丝氨酸酯酶家族成员。羧基酯酶2是一种内质网结合的水解酶，在异源生物解毒和活化含酯治疗剂中起关键作用。羧基酯酶2也可参与海洛因和可卡因等药物的解毒过程。该酶被认为在脂质代谢中起作用。
單位定義
一个酶活性单位是指在pH 7.5、25 °C下，每分钟水解1pmol对硝基苯乙酸酯所需的酶量。
外觀
以含有氯化钠、乙酸钠和20％甘油的溶液形式提供。
訊號詞
Danger
危險聲明
危險分類
Resp. Sens. 1
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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