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D4268

Sigma-Aldrich

NG,NG-二甲基精氨酸 二盐酸盐

≥98% (TLC), powder, NOS inhibitor

别名:

不对称-二甲基精氨酸, ADMA

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About This Item

经验公式（希尔记法）:
C8H18N4O2 · 2HCl
CAS号:
220805-22-1
分子量:
275.18
MDL號碼:
MFCD00270857
分類程式碼代碼:
12352209
PubChem物質ID:
24278027
NACRES:
NA.77

product name

NG,NG-二甲基精氨酸 二盐酸盐,

化驗

≥98% (TLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

room temp

SMILES 字串

Cl[H].Cl[H].CN(C)C(=N)NCCC[C@H](N)C(O)=O

InChI

1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1

InChI 密鑰

SYLNVYJOPZWPJI-ILKKLZGPSA-N

基因資訊

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

一般說明

N G 、 N G -二甲基精氨酸二盐酸盐是一种甲基化精氨酸衍生物，由肝脏产生。与肝硬化、酒精性肝炎和急性肝衰竭 (ALF) 有关。

應用

NG,NG-二甲基精氨酸二盐酸盐曾被用于：
  • 研究其对大鼠头端延髓腹外侧区(RVLM) 心血管活动的影响
  • ，作为测量L-精氨酸和二甲基精氨酸的标准
  • 来研究其对肝脏恶化的影响

生化／生理作用

体内和体外可逆的一氧化氮合成酶抑制剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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Marie Rodling Wahlström et al.
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A prospective, randomised, double-blinded, clinical trial was performed at a level 1 trauma centre to determine if a prostacyclin analogue, epoprostenol (Flolan®), could attenuate systemic inflammatory response in patients with severe traumatic brain injury (TBI). 46 patients with severe TBI
Kyoung Min Kim et al.
Cardiovascular diabetology, 16(1), 146-146 (2017-11-11)
The cardiovascular benefits of statins have been proven, but their effect on circulation in small vessels has not been examined fully. We investigated the effect of 20 mg rosuvastatin on biomarkers, including paraoxonase-1 (PON-1) and asymmetric dimethylarginine (ADMA), and on microvascular
Aleksandar Radujkovic et al.
Haematologica, 104(4), 827-834 (2018-12-06)
Increasing evidence suggests that endothelial cell distress is associated with mortality after allogeneic stem cell transplantation and acute graft-versus-host disease. Asymmetric dimethylarginine is an endogenous nitric oxide synthase inhibitor that induces endothelial cell dysfunction. We analyzed the impact of pre-transplant
José D Martins et al.
Journal of the American Heart Association, 8(7), e011536-e011536 (2019-04-02)
Background Optimally treated patients with coarctation of the aorta remain at risk for late vascular dysfunction. The effect of treatment modality on vascular function is unknown. The LOVE-COARCT (Long-term Outcomes and Vascular Evaluation After Successful Coarctation of the Aorta Treatment)
Tse-Min Lu et al.
Atherosclerosis, 254, 161-166 (2016-10-17)
Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. We measured plasma ADMA
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