311203

N^G,N^G-Dimethyl-L-arginine, Dihydrochloride

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo.

• 别名: ADMA, 2HCl, N^G,N^G-Dimethyl-L-arginine, Dihydrochloride
• 经验公式（希尔记法）: C₈H₁₈N₄O₂ · 2HCl
• CAS号: 220805-22-1
• 分子量: 275.18
• 分類程式碼代碼: 12352209
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (TLC)
• 形狀: amorphous solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: water: 50 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1
• InChI 密鑰: SYLNVYJOPZWPJI-ILKKLZGPSA-N

说明

一般說明

A cell-permeable, reversible inhibitor of nitric oxide synthase in vitro (IC₅₀ = 2-3 µM) and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

Endogenous reversible inhibitor of nitric oxide synthesis in vitro and in vivo. Causes dose-dependent vasoconstriction and bradycardic effects.

生化／生理作用

Cell permeable: yes

Primary Target
NOS in vitro

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2-3 µM inhibiting nitric oxide synthase in vitro

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

其他說明

Closs, E.I., et al. 1997. Nitric Oxide1, 65.
Faraci, F.M., et al. 1995. Am. J. Physiol.269, H1522.
Gardiner, S.M., et al. 1993. Br. J. Pharmacol. 110, 1457.
Kotani, K., et al. 1992. J. Neurochem.58, 1127.
Vallance, P., et al. 1992. Lancet339, 572.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable