所有图片(4)
About This Item
经验公式（希尔记法）:
C10H13NO4 · HCl
CAS号:
分子量:
247.68
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.77
product name
L -3,4-二羟基苯丙氨酸甲酯 盐酸盐, solid
形狀
solid
顏色
white to off-white
儲存溫度
−20°C
SMILES 字串
Cl[H].COC(=O)[C@@H](N)Cc1ccc(O)c(O)c1
InChI
1S/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/m0./s1
InChI 密鑰
WFGNJLMSYIJWII-FJXQXJEOSA-N
應用
L-3,4-二羟基苯丙氨酸甲酯盐酸盐用于：
- 治疗6-羟基多巴胺诱导的小鼠5-羟色胺神经元损伤
- 研究 B16F10 皮肤黑色素瘤细胞中酪氨酸酶活性
- 研究其对中脑神经元的神经保护作用
生化／生理作用
L-3,4-二羟基苯丙氨酸甲酯是 L-DOPA 的前体，可穿过血脑屏障。抗帕金森氏病药物 L-DOPA 甲酯在白血病和黑色素瘤中引发抗肿瘤功能。
注意
光敏性
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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The effects of central dopamine function of chronic L-DOPA (methyl ester hydrochloride) treatment of mice
Tabar J, et al.
Pharmacology, Biochemistry, and Behavior, 33(1), 139-146 (1989)
3-O-Methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of l-DOPA
Asanuma M and Miyazaki I
BMC Neuroscience, 17(1), 52-52 (2016)
Yuhan Wang et al.
Frontiers in pharmacology, 8, 935-935 (2018-01-10)
Dopamine (DA) is required for motor function in vertebrate animals including humans. The striatum, a key motor control center, receives a dense DA innervation and express high levels of DA D1 receptors (D1Rs) and D2 receptors (D2Rs). Other brain areas
Muriel Geurts et al.
Neuroscience letters, 333(2), 146-150 (2002-11-07)
The role of dopaminergic transmission on striatal mRNA levels of regulators of G protein signalling proteins RGS 2-12 was evaluated by quantitative in situ hybridisation. A single injection of L-dopa (50 mg/kg i.p.) significantly increased the RGS2 mRNA level (by
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