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一般說明
溶液应新鲜制备，并且应避光。
應用
6-羟基多巴胺合溴化氢可用于：
- 诱导小鼠模型中的帕金森病（PD）以研究tubastatin A （TBA）对SH-SY5Y细胞中核苷酸结合寡聚化结构域和富亮氨酸重复Pyrin 3序列结构域（NLRP3） 以及细胞损伤的作用。
- 诱导交感神经的药理学消融以研究肝交感神经活性（SNA）对食源性肥胖小鼠中肝脂肪变性的作用
- 诱导中脑细胞中的氧化应激以研究其对腹侧中脑的神经元细胞中p75NTR 信号传递的作用。
生化／生理作用
6-羟基多巴胺合溴化氢（6-OHDA）是一种神经毒素，可诱导氧化损伤并破坏含儿茶酚胺或交感神经末梢。它常用于诱发实验模型中的帕金森′病。6-OHDA可通过产生活性氧物质，引发细胞应激和细胞死亡而发挥细胞毒性。
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Woori Kim et al.
Neurobiology of aging, 35(7), 1712-1721 (2014-02-25)
Dopamine (DA) neurons in sporadic Parkinson's disease (PD) display dysregulated gene expression networks and signaling pathways that are implicated in PD pathogenesis. Micro (mi)RNAs are regulators of gene expression, which could be involved in neurodegenerative diseases. We determined the miRNA
Yun-Qi Xu et al.
CNS neuroscience & therapeutics, 19(3), 170-177 (2013-01-03)
In addition to their original applications for lowering cholesterol, statins display multiple neuroprotective effects. Inflammatory reactions and the PI3K/AKT/caspase 3 pathway are strongly implicated in dopaminergic neuronal death in Parkinson's disease (PD). This study aims to investigate how simvastatin affects
Julio C Tobón-Velasco et al.
Toxicology, 304, 109-119 (2013-01-01)
6-Hydroxydopamine (6-OHDA) is a neurotoxin that generates an experimental model of Parkinson's disease in rodents and is commonly employed to induce a lesion in dopaminergic pathways. The characterization of those molecular mechanisms linked to 6-OHDA-induced early toxicity is needed to
C C Real et al.
Neuroscience, 237, 118-129 (2013-02-12)
Physical exercise is known to produce beneficial effects to the nervous system. In most cases, brain-derived neurotrophic factor (BDNF) is involved in such effects. However, little is known on the role of BDNF in exercise-related effects on Parkinson's disease (PD).
Ilse S Pienaar et al.
Experimental neurology, 248, 213-223 (2013-06-19)
The pedunculopontine nucleus (PPN) controls various physiological functions, whilst being deemed a suitable target for low-frequency stimulation therapy for alleviating aspects of Parkinson's disease (PD). Previous studies showed that the PPN contains mainly cholinergic, γ-aminobutyric acid (GABA)ergic and glutamatergic neurons.
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