推荐产品
product name
1-甲基-4-苯基-1,2,3,6-四氢吡啶 盐酸盐, powder
形狀
powder
drug control
kontrollierte Droge in Deutschland
顏色
white to off-white
SMILES 字串
Cl[H].CN1CCC(=CC1)c2ccccc2
InChI
1S/C12H15N.ClH/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-7H,8-10H2,1H3;1H
InChI 密鑰
KOWJANGMTAZWDT-UHFFFAOYSA-N
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一般說明
MPTP可引起炎症、兴奋性毒性、线粒体凋亡、包涵体形成，还引起氧化应激，继而导致纹状体和黑质中的多巴胺能神经元损伤。在多巴胺能神经元中，MPTP抑制线粒体复合物I，导致线粒体功能障碍。
應用
1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐已被用于诱导动物模型中的帕金森病：
- 研究二十二碳六烯酸对神经系统中爱帕琳肽分布的作用
- 研究与神经化学缺陷相关的行为障碍
- 研究跑步机运动对神经保护和神经发炎的作用
MPTP可用于研究其对小胶质细胞先天性免疫记忆的影响。还可用于研究苯丙酸酰胺(phenylpropionamides)在帕金森病小鼠模型中的保护作用。
生化／生理作用
1-甲基-4-苯基-1,2,3,6-四氢吡啶(MPTP)是一种哌啶衍生物和多巴胺能神经毒素，可用于神经学研究。MPTP可代谢为1-甲基-4-苯基吡啶(MPP+)，使体内产生游离自由基，导致氧化应激。因此通常视MPP+为MPTP的活性代谢产物。MPTP常用于构建帕金森症(Parkinsonism)的体内研究模型。文献综述表明，MPTP可用于各种神经退行性疾病的程序性细胞死亡研究。
多巴胺能神经毒素。
警告
据报道可在人和猴中导致严重且不可逆转的帕金森症状。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 3 Oral - STOT SE 1
標靶器官
Nervous system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
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