所有图片(1)
About This Item
经验公式（希尔记法）:
C15H20O6
CAS号:
分子量:
296.32
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
推荐产品
形狀
powder
品質等級
儲存溫度
2-8°C
SMILES 字串
[H][C@]12O[C@]3([H])[C@H](O)C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2
InChI
1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChI 密鑰
LINOMUASTDIRTM-QGRHZQQGSA-N
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一般說明
脱氧雪腐镰刀菌烯醇(DON)是一种天然霉菌毒素，存在于禾谷镰刀菌(Fusarium graminearum)和大黄镰刀菌( Fusarium culmorum)中。它属于霉菌毒素的B类单端孢霉烯毒素家族。
應用
脱氧雪腐镰刀菌烯醇已用于：
- 用作霉菌毒素，诱导猪空肠上皮细胞的细胞毒性，研究酿酒酵母(Saccharomyces cerevisiae)对宿主细胞活力的保护作用。
- 诱导裸鼠毒性，研究补充益生菌（鼠李糖乳杆菌GG (LGG)或嗜酸乳杆菌 (LA)对于宿主细胞的作用
- 用作细胞荧光素酶报告基因(CALUX)测定中的甲状腺激素受体(TR)拮抗剂
生化／生理作用
脱氧雪腐镰刀菌烯醇(DON)通过抑制翻译过程，阻断DNA和RNA合成。
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Yang Liu et al.
AMB Express, 9(1), 137-137 (2019-09-05)
Deoxynivalenol (DON) is one of the mycotoxins most frequently encountering in cereal-based foods throughout the world. Saccharomyces cerevisiae was used to alleviate porcine jejunal epithelia cell (IPEC-J2) injury induced by DON in this study. The results indicated that cell viability
Toxicology of deoxynivalenol (vomitoxin).
Rotter B A.
Int J Toxicol Pharmacol Res, 48(1), 1-34 (1996)
Isabel Parraga-Aguado et al.
Journal of environmental management, 158, 74-84 (2015-05-13)
Phytomanagement in terms of phytostabilisation has been proposed as a suitable technique to decrease the environmental risks of metal(loid) enriched mine tailings. Nevertheless, at these sites some issues must be solved to assure the long-term establishment of vegetation (e.g. salinity
Miaomiao Wu et al.
PloS one, 9(7), e100591-e100591 (2014-07-02)
The mycotoxin deoxynivalenol (DON), one of the most common food contaminants, primarily targets the gastrointestinal tract to affect animal and human health. This study was conducted to examine the protective function of glutamic acid on intestinal injury and oxidative stress
Michihiro Ito et al.
Applied and environmental microbiology, 79(5), 1619-1628 (2013-01-01)
Deoxynivalenol (DON) is a natural toxin of fungi that cause Fusarium head blight disease of wheat and other small-grain cereals. DON accumulates in infected grains and promotes the spread of the infection on wheat, posing serious problems to grain production.
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