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product name
盐酸胺碘酮 盐酸盐, ≥98%
品質等級
化驗
≥98%
形狀
powder
起源
Wyeth
儲存溫度
2-8°C
SMILES 字串
C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl
InChI
1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChI 密鑰
ITPDYQOUSLNIHG-UHFFFAOYSA-N
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應用
盐酸胺碘酮是一种非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。 盐酸胺碘酮可用于废水处理厂废水中甲状腺破坏物质浓度测量研究。
盐酸胺碘酮用于研究其与半胱胺的相互作用，刺激培养的生物传感器细胞系发生自噬。也用于幼虫和成虫器官毒性基因组学筛选，分析药物的转录作用。
生化／生理作用
非选择性离子通道阻滞剂。胺碘酮诱导Ca2+即刻流入酿酒酵母中，随后发生线粒体断裂和细胞死亡。
基底
CYP2C8/9 和 CYP3A 家族（次要通路）抑制剂和底物；CYP2D6、CYP3A 家族、CYP2D6、CYP2A6、CYP2B6 去乙基形式抑制剂
訊號詞
Warning
危險分類
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
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Journal of internal medicine, 288(5), 560-569 (2020-05-18)
We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism. Here, we extended our study to a large number of cardiac
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