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Merck

A2181

Sigma-Aldrich

乙酰辅酶 A 锂盐

≥93% (HPLC)

别名:

乙酰CoA, 乙酰辅酶 A 三锂盐

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About This Item

经验公式(希尔记法):
C23H38N7O17P3S · xLi+
CAS号:
分子量:
809.57 (free acid basis)
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

品質等級

化驗

≥93% (HPLC)

形狀

powder

溶解度

H2O: soluble 100 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

[Li+].[Li+].[Li+].CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23

InChI

1S/C23H38N7O17P3S.3Li/c1-12(31)51-7-6-25-14(32)4-5-26-21(35)18(34)23(2,3)9-44-50(41,42)47-49(39,40)43-8-13-17(46-48(36,37)38)16(33)22(45-13)30-11-29-15-19(24)27-10-28-20(15)30;;;/h10-11,13,16-18,22,33-34H,4-9H2,1-3H3,(H,25,32)(H,26,35)(H,39,40)(H,41,42)(H2,24,27,28)(H2,36,37,38);;;/q;3*+1/p-3/t13-,16-,17-,18+,22-;;;/m1.../s1

InChI 密鑰

FTRFBNATWBKIQU-JHJDYNLLSA-K

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應用

乙酰辅酶A适用于CAT报告检测,通过将细胞提取物与0.1 μCi [14C]氯霉素和0.5mM乙酰辅酶A一起孵育来对氯霉素乙酰转移酶进行测定。
酶催化乙酰基转移反应中必要的辅因子。

生化/生理作用

编码乙酰辅酶A的基因的改变已与阿尔茨海默病和轻度认知障碍存在关联。该基因的缺陷可导致与阵发性呼吸暂停相关的肌无力综合征。
乙酰辅酶A是酶促的乙酰转移反应中酰基的必需辅助因子和载体。 它可通过线粒体中丙酮酸的氧化脱羧、长链脂肪酸的氧化或某些特定氨基酸的氧化降解而形成。乙酰辅酶A是柠檬酸循环(克雷布氏循环)的起始化合物。 它也是脂质生物合成的关键前体,所有脂肪酸碳的来源。 乙酰辅酶A可正向调节丙酮酸羧化酶的活性。 它是神经递质乙酰胆碱的前体。 组蛋白乙酰化酶(HAT)使用乙酰辅酶A作为乙酰基的供体,用于组蛋白和非组蛋白蛋白的翻译后乙酰化反应。

物理性質

这种湿度敏感的粉末应在−20°C下干燥储存。

準備報告

酶法制备

重構

乙酰辅酶A可以100 mg/mL溶于去离子水。 乙酰CoA可稳定于中性和中等酸性溶液,但在碱性和强酸性溶液中会水解。 按单次使用分装的水溶液可在−20°C储存最长达两周,而在−80°C最长可达6个月。

其他說明

如需更多技术信息以及辅酶A衍生物的完整列表,请访问乙酰转移试剂资源

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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