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62143

Sigma-Aldrich

林可霉素 盐酸盐

96.0-102.0% (HPLC)

别名:

Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside 盐酸盐, 林可霉素 盐酸盐

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About This Item

经验公式（希尔记法）:
C18H34N2O6S · HCl
CAS号:
859-18-7
分子量:
443.00
Beilstein:
4171650
EC號碼:
212-726-7
MDL號碼:
MFCD00083647
分類程式碼代碼:
51284507
PubChem物質ID:
329759714
NACRES:
NA.85

品質等級

200

化驗

96.0-102.0% (HPLC)

形狀

powder or crystals

雜質

≤5% water

顏色

white to off-white

溶解度

H2O: 50 mg/mL, clear, colorless to faintly yellow

抗生素活性譜

Gram-positive bacteria

作用方式

protein synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI 密鑰

POUMFISTNHIPTI-BOMBIWCESA-N

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相关类别

一般說明

化学结构：大环内酯

生化／生理作用

作用方式：林可霉素可通过在23S rRNA的肽基转移酶环区域内形成交联来抑制细菌蛋白质的合成。†

抗菌谱：盐酸林可霉素对革兰氏阳性菌有效。

準備報告

该产品在水中的溶解度为50 mg/mL，产生澄清无色的溶液。

其他說明

保存于密闭容器内，置于干燥通风处。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

分析证书(COA)

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J Slots et al.
Antimicrobial agents and chemotherapy, 18(1), 9-12 (1980-07-01)
The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less
S Takebe et al.
Journal of clinical microbiology, 20(5), 869-873 (1984-11-01)
When Ureaplasma urealyticum T-960 was inoculated into normal human urine (10(8) viable cells per ml of urine), a white precipitate formed, with an increase in pH of the infected urine. This precipitate was identified as a mixture of struvite and
H Malke et al.
Antimicrobial agents and chemotherapy, 19(1), 91-100 (1981-01-01)
The phenomenon of zonal resistance to lincomycin, which is characteristic of most clinical isolates with lincomycin resistance in Streptococcus pyogenes, has been studied. These strains grow within a defined concentration range of lincomycin (approximately 60 to 200 microgram/ml), or at
Ulrich Schreiber et al.
Photosynthesis research, 114(3), 165-177 (2013-02-15)
A new type of multi-color PAM chlorophyll fluorometer (Schreiber et al. 2012) was applied for measurements of photodamage to photosystem II (PS II) in optically thin suspensions of Chlorella (200 μg Chl l(-1)) in the presence of 1 mM lincomycin.
Isaac M Hagenbuch et al.
Water research, 46(16), 5028-5036 (2012-07-24)
The role that antibiotics and other "emerging contaminants" play in shaping environmental microbial communities is of growing interest. The use of the prokaryotic metabolic inhibitors tylosin (T), lincomycin (L), and ciprofloxacin (C) in livestock and humans is both global and
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Inhibition of Protein Synthesis by Antibiotics

Protein synthesis is a complex, multi-step process involving many enzymes as well as conformational alignment. However, the majority of antibiotics that block bacterial protein synthesis interfere with the processes at the 30S subunit or 50S subunit of the 70S bacterial ribosome.

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