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Sigma-Aldrich

聚乙二醇12羟基硬脂酸酯

别名:

Solutol® HS 15, 聚乙二醇（15）-羟基硬脂酸酯, 聚氧乙烯化的12-羟基硬脂酸

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About This Item

CAS号:
70142-34-6
分類程式碼代碼:
12161900
PubChem物質ID:
329756293
NACRES:
NA.25

描述

non-ionic

品質等級

100

形狀

paste

成份

free macrogoly% (27.0 - 39.0 g/100g (%))

雜質

acetic acid (≤ 0.5 g/100g (%))
 water (≤ 0.5 g/100g (%))
≤0.05% acetic acid
≤0.05% water
≤1 mg/kg ethylene oxide ((ppm))
≤1 mg/kg ethylene oxide
≤1 mg/kg nickel ((ppm))
≤1 mg/kg nickle
≤10 mg/kg dioxane ((ppm))
≤10 mg/kg dioxane
≤10 mg/kg heavy metals
≤620 mg/kg Diethylene glycol
≤620 mg/kg diethylene glycol ((ppm))
≤620 mg/kg ethylene glycol ((ppm))
≤620 mg/kg ethylene glycol
<10 mg/kg heavy metals ((ppm))

燃燒殘留物

(≤ 0.3 g/100g (%))

pH值

5.0-7.0 (1 g/10 mL in H2O)

mp

25 - 30  °C (77 - 86 °F)

酸價

≤1.0 mg KOH/g

羥值

90‑110 mg KOH/g

碘值

≤2.0 g I2/100 g

過氧化值

≤3.0 meq/kg

皂化值

53‑63 mg KOH/g

溶解度

water: 200 g/L at 30 °C (86 °F)

密度

1.048 g/cm3 at 20 °C (68 °F)
1.03 g/cm3 at 60 °C (140 °F)

負離子痕跡

<1 ppm (Ethylene Oxide)
<10 ppm (Dioxane)

正離子痕跡

Ni: <1 ppm
heavy metals: <10 ppm

應用

sample preservation

SMILES 字串

C(CCCCC(CCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)O)CCCCC(=O)O

InChI

1S/C47H94O19/c48-15-17-53-19-21-55-23-25-57-27-29-59-31-33-61-35-37-63-39-41-65-43-45-66-44-42-64-40-38-62-36-34-60-32-30-58-28-26-56-24-22-54-20-18-52-16-11-7-6-9-13-46(49)12-8-4-2-1-3-5-10-14-47(50)51/h46,48-49H,1-45H2,(H,50,51)

InChI 密鑰

CYAMZYIUAHNTBO-UHFFFAOYSA-N

相关类别

一般說明

聚乙二醇12羟基硬脂酸酯是一种不依赖pH值的非离子表面活性剂，是一种有效的增溶剂和乳化剂。它可溶于水介质和极性有机溶剂，但不溶于非极性溶剂。其结构为12-羟基硬脂酸（亲脂部分）和聚乙二醇（亲水部分）。

應用

  • 聚乙二醇12羟基硬脂酸酯已用于：
  • 溶解于地塞米松（DEX），以将其腹腔注射到小鼠体内，测试其握力，进而测量肌肉力量
  • 以罗氟司特制剂治疗家兔和豚鼠，以研究臭氧诱导的剧烈咳嗽(hypertussive)反应的机制和药理敏感性
  • 溶解非奈利酮，以进行口服应用的体内研究

生化／生理作用

聚乙二醇12羟基硬脂酸酯(12-Hydroxy-octadecanoic acid polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl))主要用作肠外和口服制剂的增溶剂。它是化合物的体外筛选和体内疗效研究的首选。聚乙二醇12羟基硬脂酸酯还因其增溶特性和安全性，可用于眼科、大分子、栓剂和蛋白质制剂中。通常可形成10-15纳米的胶束。聚乙二醇12羟基硬脂酸酯可用于开发微乳液IV制剂(micro-emulsion IV formulations)。

其他說明

聚乙二醇12羟基硬脂酸酯是一种非离子型去污剂，由15摩尔环氧乙烷与1摩尔12-羟基硬脂酸反应生成。
如需了解生化试剂系列的更多信息，请填写此表。

法律資訊

Solutol is a registered trademark of BASF SE

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

防範說明

P280

危險分類

Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 1

閃點（°F）

521.6 °F

閃點（°C）

272 °C

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The objective of the present study was to design a novel microemulsion in situ electrolyte-triggered gelling system for ophthalmic delivery of a lipophilic drug, cyclosporine A (CsA). A CsA-loaded microemulsion was prepared using castor oil, Solutol HS 15 (surfactant), glycerol
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