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Merck

42623

Sigma-Aldrich

丁酰基- L -肉碱

≥97.0% (TLC)

别名:

C4-肉碱, 丁酰基- L -肉碱, (2 R )-3-羧基- N N N -三甲基-2-(1-氧代丁氧基)-1-丙胺 内盐

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About This Item

经验公式(希尔记法):
C11H21NO4
CAS号:
分子量:
231.29
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.26

产品名称

丁酰基- L -肉碱, ≥97.0% (TLC)

品質等級

化驗

≥97.0% (TLC)

形狀

powder, crystals or chunks

光學活性

[α]/D -23±2°, c = 1 in H2O

顏色

white to off-white

儲存溫度

2-8°C

SMILES 字串

C[N+](C)(C)C[C@H](OC(CCC)=O)CC([O-])=O

InChI

1S/C11H21NO4/c1-5-6-11(15)16-9(7-10(13)14)8-12(2,3)4/h9H,5-8H2,1-4H3/t9-/m1/s1

InChI 密鑰

QWYFHHGCZUCMBN-SECBINFHSA-N

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應用


  • 铅暴露诱导大鼠模型的代谢重编程。:Mani MS等人的这项研究调查了铅暴露对大鼠模型代谢的影响,重点关注了受影响的生化途径。该研究强调了丁酰基肉碱在抵消铅引起的代谢紊乱方面的作用,表明它在减轻重金属毒性方面具有潜在的治疗用途(Mani et al., 2020)。

生化/生理作用

酰基辅酶A脱氢酶,短链(SCAD)缺乏症患者,急性酸中毒和全身性肌肉无力的婴儿以及肌肉局部慢性肌病的中年患者的丁酰肉碱升高;极长链酰基辅酶A脱氢酶缺乏症和乳糜泻

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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R Golan et al.
International journal of andrology, 6(4), 349-357 (1983-08-01)
Bioautography of human semen demonstrated the presence of L-carnitine, acetylcarnitine, propionylcarnitine and C4-acylcarnitines (butyrylcarnitines). In studies designed to ascertain the organs secreting these compounds into semen it was found that: Quantitative analyses of semen obtained pre- and post-vasectomy showed markedly
Sarah P Young et al.
Clinica chimica acta; international journal of clinical chemistry, 337(1-2), 103-113 (2003-10-22)
Homozygosity and compound heterozygosity for the short chain acyl-CoA dehydrogenase (SCAD) gene sequence variants 625G-->A and 511C-->T are associated with ethylmalonic aciduria (EMA), a biochemical indicator of SCAD deficiency. The clinical and biochemical implications of these variants are not fully
S Benito et al.
The Analyst, 143(18), 4448-4458 (2018-08-29)
Pediatric chronic kidney disease (CKD) is a clinical syndrome characterized by renal hypofunction occurring due to gradual and irreversible kidney damage that can further progress over time. New biomarkers may help early diagnosis of pediatric patients suffering from CKD and
A Bhala et al.
The Journal of pediatrics, 126(6), 910-915 (1995-06-01)
We identified two additional patients with short-chain acyl-coenzyme A (CoA), further characterized the clinical and biochemical features of this defect, and compared it with other fatty acid oxidation defects. We have measured the in vitro short-chain acyl-coenzyme A dehydrogenase (SCAD)
Josiane Joseph et al.
Metabolites, 8(4) (2018-10-05)
Duchenne muscular dystrophy (DMD) is a musculoskeletal disorder that causes severe morbidity and reduced lifespan. Individuals with DMD have an X-linked mutation that impairs their ability to produce functional dystrophin protein in muscle. No cure exists for this disease and

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