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Merck

S9251

Sigma-Aldrich

对氨基苯磺酰胺

≥98%

别名:

对氨基苯磺酰胺

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About This Item

线性分子式:
H2NC6H4SO2NH2
CAS号:
分子量:
172.20
Beilstein:
511852
EC號碼:
MDL號碼:
分類程式碼代碼:
51283932
eCl@ss:
39093202
PubChem物質ID:
NACRES:
NA.76

品質等級

化驗

≥98%

形狀

powder or crystals

顏色

white to off-white

mp

164-166 °C (lit.)

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

DNA synthesis | interferes
enzyme | inhibits

SMILES 字串

Nc1ccc(cc1)S(N)(=O)=O

InChI

1S/C6H8N2O2S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H2,8,9,10)

InChI 密鑰

FDDDEECHVMSUSB-UHFFFAOYSA-N

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一般說明

化学结构:磺胺

生化/生理作用

磺胺类抗生素通过抑制酶二氢蝶酸合成酶能够阻止二氢叶酸合成。
作用模型:一种二氢蝶酸合成酶竞争性抑制剂阻止二氢叶酸合成。
抗微生物谱:革兰氏阳性,革兰氏阴性,衣原体病
抗性模型:二氢蝶酸合成酶取代或二氢叶酸合成取代途径。

其他說明

保持容器密闭,置于干燥通风处。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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I Meneau et al.
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Failure of anti-Pneumocystis jiroveci prophylaxis with sulfa drugs is associated with mutations within the putative active site of the fungal dihydropteroate synthase (DHPS), an enzyme encoded by the multidomain FAS gene. This enzyme is involved in the essential biosynthesis of
Edward E Knaus et al.
Bioorganic & medicinal chemistry letters, 21(19), 5892-5896 (2011-08-20)
A series of compounds incorporating regioisomeric phenylethynylbenzenesulfonamide moieties has been investigated for the inhibition of four human carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, hCA I, II, IX and XII. Inhibition between the low nanomolar to the milliomolar range has been
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 20(7), 2178-2182 (2010-03-10)
A beta-carbonic anhydrase (CA, EC 4.2.1.1) from the bacterial pathogen Brucella suis, bsCA 1, has been cloned, purified characterized kinetically and for inhibition with a series of water soluble glycosylated sulfanilamides. bsCA 1 has appreciable activity as catalyst for the
Claudia Temperini et al.
Journal of medicinal chemistry, 53(2), 850-854 (2009-12-24)
Coumarins constitute a general and totally new class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), binding at the entrance of the active site cavity. We report here that the coumarin-binding site in CAs may interact with
Penghua Wang et al.
Water research, 45(16), 5015-5026 (2011-08-02)
A novel carbon-sensitized and nitrogen-doped TiO2 (C/N-TiO2) was synthesized by a facile sol-gel method using titanium butoxide as both titanium precursor and carbon source, and nitric acid as nitrogen source. The calcination temperature had a great effect on the crystal

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