AB15242
Anti-zDHHC8 Antibody
from rabbit, purified by affinity chromatography
别名:
Zinc finger DHHC domain-containing protein 8, Zinc finger protein 378, membrane-associated DHHC8 zinc finger protein, zinc finger, DHHC domain containing 8, zinc finger, DHHC domain like containing 1, zinc finger, DHHC-type containing 8
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About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
無性繁殖:
polyclonal
application:
WB
物種活性:
rat, human
技術:
western blot: suitable
citations:
1
推荐产品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
rat, human
物種活性（以同源性預測）
horse, bovine, Xenopus, chicken, pig, chimpanzee, ape, opossum, mouse, dog
技術
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
chimpanzee ... Zdhhc8(458662)
human ... ZDHHC8(29801)
一般說明
Six genes in the 1.5 Mb region of chromosome 22 deleted in DiGeorge/22q11 deletion syndrome–Mrpl40, Prodh, Slc25a1, Txnrd2, T10, and Zdhhc8–encode mitochondrial proteins. All six genes are expressed in the
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
brain, and maximal expression coincides with peak forebrain synaptogenesis shortly after birth. Furthermore, their protein products are associated with brain mitochondria, including those in synaptic terminals. Among the six, only Zddhc8 influences mitochondria-regulated apoptosis when overexpressed, and appears to interact biochemically with established mitochondrial proteins. Zdhhc8 has an apparent interaction with Uqcrc1, a component of mitochondrial complex III. The two proteins are coincidently expressed in pre-synaptic processes; however, Zdhhc8 is more frequently seen in glutamatergic terminals (1).
特異性
Cat. AB15242 recognizes the C-terminus of zDHHC8.
免疫原
Epitope: C-Terminus
Syntheic linear peptide.
應用
Anti-zDHHC8 Antibody is an antibody against zDHHC8 for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
品質
Routinely evaluated by western blot in fetal human brain lysate.
標靶描述
~71 kDa
外觀
ImmunoAffinity Purified
Purified in PBS with 0.05% NaN3
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.
分析報告
Control
Fetal human brain
Fetal human brain
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Francisco S Mesquita et al.
Developmental cell, 56(20), 2790-2807 (2021-10-03)
SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such as spike, responsible for target-cell binding and virus fusion. We found that during SARS-CoV-2 infection, spike becomes lipid modified, through the sequential action of the S-acyltransferases ZDHHC20
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