14-520-M

Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg

Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

• 分類程式碼代碼: 12352200
• eCl@ss: 32160405
• NACRES: NA.32

属性

• 生物源: human
• 品質等級: 100
• 重組細胞: expressed in E. coli
• 分子量: M_w 61 kDa
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable (kinase)
• NCBI登錄號: NM_001893.3; NM_139062.1
• UniProt登錄號: P48730
• 基因資訊: human ... CSNK1D(1453)

说明

一般說明

Research area: Cell signaling

Research Category: Metabolism Research

Subcategory: Obesity

Protein Target: CK1γδ

Target Sub-Family: CK1

Casein Kinase 1δ (CK1δ ) is a serine/threonine kinase that belong to the family of casein kinase 1. The protein structure consists of anti-parallel β-sheet strands at N-terminal lobe (N-lobe) and α-helices and loop structures at the larger C-terminal lobe (C-lobe).

應用

Research Category
Metabolism

Research Sub Category
Obesity

Metabolic Disorders

生化／生理作用

Casein Kinase 1δ (CK1δ) is implicated in multiple cellular processes, including membrane trafficking, cytokinesis, circadian rhythm, and tumorigenesis. It interacts with critical molecules within cancer-related signaling pathways, such as Wnt/β-catenin, PI3K/AKT, and Hedgehog. Therefore, mutations or overexpression of the CK1δ coding gene can potentially contribute to the onset and progression of cancer.

包裝

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.

品質

routinely evaluated by phosphorylation of KRRRALS(p)VASLPGL

外觀

Glutathione-agarose

儲存和穩定性

6 months at -20°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1