推荐产品
生物源
bovine
品質等級
形狀
lyophilized
比活性
≥1800 NIH units/mg protein
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
溶解度
water: soluble
運輸包裝
ambient
儲存溫度
−20°C
一般說明
凝血酶是钠激活的II型酶。这种丝氨酸蛋白酶包含两个阴离子结合的外源性位点，即ABE-I和ABE-II。凝血酶由酶原凝血酶原（因子II）在肝脏中合成。牛A-凝血酶由轻链（A链）和重链（B链）组成。这两条链通过非共价相互作用和一个双硫键连接。
應用
牛用高活性凝血酶已用于：
- 刺激LNCaP细胞和研究G-蛋白-偶联受体（GPCR）活性的影响
- 纤维蛋白凝胶制备
- 通过纤维蛋白原凝胶法制备纤维蛋白原凝胶
生化／生理作用
凝血酶可将纤维蛋白原转换成纤维蛋白并激活因子V、VIII、XI和XIII。它可促进血小板活化和血管收缩。凝血酶可稳定纤维蛋白聚合物。它在凝血级联系统的最后阶段起着至关重要的作用。
警告
毒性：有害（C）
外觀
使用200 mM NaCl、50 mM枸橼酸盐缓冲液、1 ml 0.1% PEG（pH 6.5）冷冻干燥。
分析報告
通过SDS-PAGE从均质凝血酶原完成激活
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Kitchens CS, et al.
Consultative Hemostasis and Thrombosis null
Segall JA and Liem TK
Congenital and Acquired Hypercoagulable Syndromes, 339-346 (2007)
Diana L Diesen et al.
Vascular, 16 Suppl 1, S29-S36 (2008-03-01)
Thrombin is a common hemostatic drug used in surgical practice for over 100 years because of its simplicity and efficacy. Thrombin converts fibrinogen to fibrin, activates platelets, and induces vascular contraction. It is available in multiple forms, including human thrombin
Isis S R Carter et al.
Thrombosis, 2010, 416167-416167 (2010-01-01)
Although prothrombin is one of the most widely studied enzymes in biology, the role of the thrombin A-chain has been neglected in comparison to the other domains. This paper summarizes the current data on the prothrombin catalytic domain A-chain region
Li Xiao et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-13)
Ultraviolet-A (UVA) irradiation induces harmful effects on skin cells and accelerates skin aging through oxidative stress. In this study, the effects of a hydrogen-generating silica material named ULH-002 against UVA injuries in human cells and 3D skin equivalents were investigated.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门