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Merck
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主要文件

580549

Millipore

牛磺酸去氧胆酸，钠盐

Tauroursodeoxycholic is a detergent useful for the solubilization of lipids and membrane-bound proteins.

别名:

牛磺酸去氧胆酸，钠盐, 牛磺熊脱氧胆酸钠

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About This Item

经验公式（希尔记法）:
C26H44NO6S · Na
CAS号:
35807-85-3
分子量:
521.69
MDL號碼:
MFCD31725069
分類程式碼代碼:
12352106
NACRES:
NA.21

描述

RTECS - KI7372500

品質等級

100

化驗

≥97% (TLC)

形狀

solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze

顏色

white

溶解度

water: 100 mg/mL

運輸包裝

ambient

儲存溫度

15-25°C

SMILES 字串

[S](=O)(=O)(O)CCNC(=O)CC[C@H]([C@@H]1[C@@]2(C(C3[C@H](C[C@H]4[C@@](C3CC2)(CC[C@H](C4)O)C)O)CC1)C)C

InChI

1S/C26H45NO6S/c1-16(4-7-23(30)27-12-13-34(31,32)33)19-5-6-20-24-21(9-11-26(19,20)3)25(2)10-8-18(28)14-17(25)15-22(24)29/h16-22,24,28-29H,4-15H2,1-3H3,(H,27,30)(H,31,32,33)/t16-,17+,18-,19-,20?,21?,22+,24?,25+,26-/m1/s1

InChI 密鑰

BHTRKEVKTKCXOH-AYSJQVDDSA-N

相关类别

一般說明

用于溶解脂质和膜结合蛋白质的洗涤剂。对大鼠体内的疏水性胆盐具有冷冻保护作用。据报道也可抑制体外胃蛋白酶活性。

應用


  • 内质网应激的抑制以及血管紧张素转换酶2的激活：预防1型糖尿病大鼠内皮功能障碍的新方法: 本研究的亮点是牛磺脱氧胆酸钠减少内质网应激的功效，表明其在预防糖尿病血管并发症方面的实用性((Gaikwad AB et al., 2022)。

警告

毒性：标准处理（A）

其他說明

Ozcan, U., et al. 2006.Science313, 1137.
Miyake, H., et al. 1999.Dig.Dis.Sci.44, 197.
Eto, T. and Tompkins, R.K.1985.Am. J. Surg.150, 564.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Crystal L Kraft et al.
Oncotarget, 8(61), 102923-102933 (2017-12-22)
Long-lived multipotent stem cells (ISCs) at the base of intestinal crypts adjust their phenotypes to accommodate normal maintenance and post-injury regeneration of the epithelium. Their long life, lineage plasticity, and proliferative potential underlie the necessity for tight homeostatic regulation of
Yaqin Chen et al.
PloS one, 8(10), e81379-e81379 (2013-11-28)
Adipocytes behave as a rich source of adipokines, which may be the link between obesity and its complications. Endoplasmic reticulum (ER) stress in adipocytes can modulate adipokines secretion. The aim of this study is to evaluate the effect of oxidized
Xiaoling Li et al.
The Journal of biological chemistry, 293(14), 5160-5171 (2018-02-25)
The liver is a major organ in lipid metabolism, and its malfunction leads to various diseases. Nonalcoholic fatty liver disease, the most common chronic liver disorder in developed countries, is characterized by the abnormal retention of excess lipid within hepatocytes
Emily M Nakada et al.
JCI insight, 4(9) (2019-05-03)
Conjugated bile acids (CBAs), such as tauroursodeoxycholic acid (TUDCA), are known to resolve the inflammatory and unfolded protein response (UPR) in inflammatory diseases, such as asthma. Whether CBAs exert their beneficial effects on allergic airway responses via 1 arm or
Isabel Castro et al.
Rheumatology (Oxford, England), 59(4), 742-753 (2019-08-05)
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration and protection of the oral mucosa. The aim of this study was to evaluate if cytokines induce aberrant mucin
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