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描述
Tunicamycin, Streptomyces lysosuperficus
品質等級
化驗
≥98% (A+B+C+D, HPLC)
形狀
powder
製造商／商標名
Calbiochem®
溶解度
DMSO: 10 mg/mL
DMF: soluble
pyridine: soluble
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C30H46N4O16/c1-11(2)5-4-6-16(38)32-19-23(43)20(40)14(47-29(19)50-28-18(31-12(3)36)22(42)21(41)15(10-35)48-28)9-13(37)26-24(44)25(45)27(49-26)34-8-7-17(39)33-30(34)46/h4,6-8,11,13-15,18-29,35,37,40-45H,5,9-10H2,1-3H3,(H,31,36)(H,32,38)(H,33,39,46)/b6-4+/t13?,14-,15-,18-,19-,20+,21-,22-,23-,24+,25-,26-,27-,28-,29-/m1/s1
InChI 密鑰
ZHSGGJXRNHWHRS-PEALBESXSA-N
一般說明
一种可抑制N-连接糖基化并阻止N-糖苷蛋白-碳水化合物键形成的核苷抗生素。对革兰氏阳性细菌、酵母、真菌和病毒具有体外活性。抑制人类T淋巴母细胞上功能性凝血酶受体的表达。还可抑制细胞中凝血酶诱导的Ca2+流通。
一种可抑制N-连接糖基化并阻止N-糖苷蛋白-碳水化合物键形成的核苷抗生素。对革兰氏阳性细菌、酵母、真菌和病毒具有体外活性。抑制人类T淋巴母细胞上功能性凝血酶受体的表达。还可抑制细胞中凝血酶诱导的Ca2+流通。还可以提供在DMSO（货号504570）中的25 mM溶液。
生化／生理作用
次要靶标
细胞中凝血酶诱导的Ca2+流通。
细胞中凝血酶诱导的Ca2+流通。
首要靶标
N-连接糖基化
N-连接糖基化
警告
毒性：高毒性 & 致癌性/致畸性（I）
準備報告
可通过在pH 8.0至10.0的H₂O中稀释或用pH >7.0的适当缓冲液从DMSO储备液中制备水溶液。
重構
可通过在pH 8.0至10.0的H₂O中稀释或用pH >7.0（>8.0更好）的适当缓冲液从DMSO储备液中制备水溶液。
溶解后，等分并冷冻保存（-20°C）。储备液可在-20°C最长稳定2周。
其他說明
Tordai, A., et al. 1995.Biochem.Biophys.Res. Commun.206, 857.
Price, B.D., et al. 1992.J. Cell Physiol.152, 545.
Price, B.D., et al. 1992.J. Cell Physiol.152, 545.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 1 Oral
儲存類別代碼
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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