393204

4-Hydroxynonenal

≥98% (HPLC), liquid, lipid peroxidation marker, Calbiochem^®

• 别名: 4-Hydroxynonenal
• 经验公式（希尔记法）: C₉H₁₆O₂
• CAS号: 75899-68-2
• 分子量: 156.22
• 分類程式碼代碼: 12352114
• NACRES: NA.77

属性

• product name: 4-Hydroxynonenal, 4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.
• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 溶解度: ethanol: 10 mg/mL
• 儲存溫度: −70°C
• InChI: 1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+
• InChI 密鑰: JVJFIQYAHPMBBX-FNORWQNLSA-N

说明

一般說明

4-Hydroxynonenal, CAS 75899-68-2, is a major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation.

A major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca²⁺ and irreversibly inhibits Na⁺, K⁺-ATPase activity (IC₅₀ = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).

A major aldehydic product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages. An inhibitor of State 3 respiration at micromolar levels that causes a transient increase in cytosolic Ca²⁺. Irreversibly inhibits Na⁺-K⁺-ATPase activity (IC₅₀ = 120 µM).

生化／生理作用

Primary Target
Na⁺, K⁺-ATPase activity

Product does not compete with ATP.

Target IC₅₀: 120 µM against Na⁺, K⁺-ATPase activity

警告

Toxicity: Flammable (J)

外觀

Supplied at 10 mg/ml in ethanol

重構

Following initial thaw, aliquot and freeze (-70°C).

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Soh, Y., et al. 2000. Mol. Pharmacol.58, 535.
Carini, R., et al. 1996. Biochem. Biophys. Res. Commun.218, 772.
Li, L., et al. 1996. Toxicol.Appl. Pharmacol.139, 135.
Siems, W.G., et al. 1996. Free Radic. Res.20, 215.
Ullrich, O., et al. 1996. Free Radic. Res.24, 421.
van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
Esterbauer, H., et al. 1991. Free Radic. Biol. Med.11, 81.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H225,H319
• 防範說明: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Flam. Liq. 2
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 57.2 °F - closed cup
• 閃點（°C）: 14 °C - closed cup