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Merck
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文件

189826

Sigma-Aldrich

5-氮杂-2′-脱氧胞苷酸

InSolution, ≥98%, DNA methyltransferase inhibitor

别名:

InSolution 5-氮杂-2′-脱氧胞苷酸, 地西他滨

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About This Item

经验公式（希尔记法）:
C8H12N4O4
CAS号:
2353-33-5
分子量:
228.21
MDL號碼:
MFCD00043011
分類程式碼代碼:
12352200

品質等級

100

化驗

≥98% (HPLC)

形狀

liquid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)

InChI 密鑰

XAUDJQYHKZQPEU-UHFFFAOYSA-N

一般說明

一种作为DNA甲基转移酶抑制剂的胞嘧啶类似物。在TRAIL抗性细胞系中恢复caspase-8和caspase-10 mRNA和蛋白表达以及TRAIL（肿瘤坏死因子相关凋亡诱导配体）敏感性。也增强HDAC（组蛋白去乙酰化酶）抑制剂诱导的凋亡。另提供该化合物的固体形式（目录号189825）。

包裝

用惰性气体包装

警告

毒性：监管审查（Z）

外觀

100 mM（10 mg/438 µl）5-氮杂-2ʹ-脱氧胞苷（目录编号189825）的DMSO溶液。

其他說明

Eggert, A., et al. 2001.Cancer Res.61, 1314.
Takebayashi, S., et al. 2001.Biochem.Biophys.Res. Commun.288, 921.
Zhu, W.G., et al. 2001.Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000.Cancer Res.60, 4315.
Haaf, T. 1995.Pharmacol.Ther.65, 19.
Jones, P.A., and Taylor, S.M.1980.Cell20, 85.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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