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品質等級
化驗
≥85% (HPLC)
形狀
solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
顏色
red-purple
輸入
sample type intact cells
溶解度
DMSO: 20 mg/mL
ethanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
−20°C
InChI
1S/C62H87N13O16/c1-26(2)42-59(85)74-21-17-19-36(74)57(83)70(13)24-38(76)72(15)48(28(5)6)61(87)89-32(11)44(55(81)66-42)68-53(79)34-23-35(63)30(9)51-46(34)65-47-40(41(64)50(78)31(10)52(47)91-51)54(80)69-45-33(12)90-62(88)49(29(7)8)73(16)39(77)25-71(14)58(84)37-20-18-22-75(37)60(86)43(27(3)4)67-56(45)82/h23,26-29,32-33,36-37,42-45,48-49H,17-22,24-25,63-64H2,1-16H3,(H,66,81)(H,67,82)(H,68,79)(H,69,80)
InChI 密鑰
YXHLJMWYDTXDHS-UHFFFAOYSA-N
一般說明
7-氨基放线菌素 D 与其母体分子（放线菌素 D）一样，是一种 DNA 嵌入剂，具有抗菌特性。对某些白血病和肉瘤具有抑制生长活性。荧光激发和发射最大值分别为 500 nm 和 672 nm。与 DNA 形成复合物，在 555 nm 处吸收并在 655 nm 处发射。可用于区分早期凋亡细胞（已失去膜完整性）与凋亡和活细胞。已用于 DNA 分析，并作为染色体结构和功能的探针。
7-氨基放线菌素 D 是一种不可渗透膜的荧光 DNA 嵌入剂。像它的母体化合物（放线菌素 D，货号 114666）一样，7-AAD 对某些白血病和肉瘤具有抗菌特性和生长抑制活性。可用于流式细胞术和荧光显微镜检查。用于染色无活力的细胞和鉴定凋亡细胞。与 FITC 和 PE 细胞表面染色兼容。吸收/发射最大值如下：未结合（激发500 nm，发射波长：672 nm）和 DNA 结合（激发555 nm，发射波长：655 nm）。λmax 528 nm ± 2；εmax = 22,700 ± 5,000 M-1 cm-1
生化／生理作用
主靶
白血病和肉瘤
白血病和肉瘤
警告
毒性：高毒性（H）
準備報告
仅在使用前再用水相缓冲液进行稀释。
重構
复溶后，分装，用惰性气体吹扫，然后冻存（-20°C）。储备溶液在-20°C下可稳定保存2个月。
其他說明
Schmid, I., et al. 1994.J. Immunol. Methods170, 145.
Raza, A., et al. 1993.Carcinogenesis14, 103.
Chen, F.M.1992.Biochemistry31, 6223.
Schmid, I., et al. 1992.Cytometry13, 204.
Toba, K., et al. 1992.Cytometry13, 60.
Sengupta, S.K., et al. 1975.J. Med. Chem.18, 1175.
Raza, A., et al. 1993.Carcinogenesis14, 103.
Chen, F.M.1992.Biochemistry31, 6223.
Schmid, I., et al. 1992.Cytometry13, 204.
Toba, K., et al. 1992.Cytometry13, 60.
Sengupta, S.K., et al. 1975.J. Med. Chem.18, 1175.
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法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 2 Oral
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類（WGK）
WGK 3
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