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形狀
powder
包裝
pkg of 1 × 10 mg (790310P-10mg)
pkg of 2 × 100 mg (790310P-200mg)
pkg of 5 × 100 mg (790310P-500mg)
pkg of 1 × 25 mg (790310P-25mg)
製造商／商標名
Avanti Research™ - A Croda Brand 790310P
應用
advanced drug delivery
脂質類型
cationic lipids
transfection
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
转染试剂I包含阳离子脂质1,2-二油酰基氧基丙基）-N,N,N-三甲基氯化铵(DOTAP)和中性脂质DOPE（1,2-二油酰基-sn-甘油-3-磷酸乙醇胺）。DOTAP是一种具有双链季铵的表面活性剂。DOTAP/DOPE脂质体具有层状和倒六角形结构。
應用
转染试剂I已与胆固醇一起用于脂质体的制备，用于小鼠胚胎成纤维细胞中基于荧光的活细胞成像研究。它可用于将DNAzyme（Dz13）转染到静脉中。
生化／生理作用
转染试剂I用于大型单层阳离子脂质体(LUV)的制备和脂质复合物的产生。它提高了转染效率。DOTAP/DOPE（1,2-二油酰基氧基丙基）-N,N,N-三甲基氯化铵/（1,2-二油酰基-sn-甘油-3-磷酸乙醇胺）是用于人类给药的安全转染剂。它抑制血管增厚，是用于冠状动脉搭桥术(CABG)的有前途的候选药物。
包裝
5 mL透明玻璃密封安瓿（790310P-10mg)
5 mL透明玻璃密封安瓿（790310P-200mg)
5 mL透明玻璃密封安瓿（790310P-25mg)
5 mL透明玻璃密封安瓿（790310P-500mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
閃點（°F）
No data available
閃點（°C）
No data available
Yue Li et al.
International journal of cardiology, 168(4), 3659-3664 (2013-07-28)
Coronary artery bypass grafting (CABG) is among the most commonly performed heart surgical procedures. Saphenous vein graft failure due to stenosis impedes the longer-term success of CABG. A key cellular event in the process of vein graft stenosis is smooth
Daniele Pezzoli et al.
Methods in molecular biology (Clifton, N.J.), 1025, 269-279 (2013-08-07)
Efficient delivery of nucleic acids into cells is a promising technique to modulate cellular gene expression for therapeutic and research applications. Cationic lipid-based liposomes represent one of the most intensively studied and employed nonviral vectors. They are positively charged at
DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery: zeta potential measurements and electron spin resonance spectra
Ciani L, et al.
Biochimica et Biophysica Acta - Biomembranes, 1664(1), 70-79 (2004)
Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1, 2-dioleoyl-3-trimethylammonium propane (DOTAP)/1, 2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE)
Li Y, et al.
International Journal of Cardiology, 168(4), 3659-3664 (2013)
Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
Roberts R, et al.
Autophagy, 9(5), 667-682 (2013)
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