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化驗
≥98%
顏色
yellow to brown
mp
154-156 °C (lit.)
溶解度
acetone: soluble, clear to hazy
儲存溫度
−20°C
SMILES 字串
[O-][N+](=O)c1cc[n+]([O-])c2ccccc12
InChI
1S/C9H6N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6H
InChI 密鑰
YHQDZJICGQWFHK-UHFFFAOYSA-N
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一般說明
4-硝基喹啉N-氧化物是一种广泛应用于化学研究和开发的喹啉衍生物。
應用
4-硝基喹啉 N-氧化物已被用作模型化合物以研究其致癌作用。
生化／生理作用
在试验条件下可诱发皮肤和肺肿瘤。
訊號詞
Danger
危險聲明
危險分類
Carc. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
The antimutagenic effect of monoterpenes against UV-irradiation-, 4NQO-and t-BOOH-induced mutagenesis in coli.
Nikolic B, et al.
Archives of Biological Sciences, 63(1), 117-128 (2011)
Interplay of DNA repair, homologous recombination, and DNA polymerases in resistance to the DNA damaging agent 4-nitroquinoline-1-oxide in Escherichia coli.
Williams AB, et al.
DNA Repair, 9(10), 1090-1097 (2010)
Ye Du et al.
Environment international, 135, 105369-105369 (2019-12-17)
Effluents from wastewater treatment plants (WWTPs) may contain various pollutants with potential toxic effects. Ozonation is widely applied to purify wastewater, which may influence the toxicity and water quality indices simultaneously. The main goal of this study was to reveal
Jing Li et al.
Oral oncology, 49(4), 299-305 (2012-11-29)
Lymph node metastasis is one of the most important prognostic factors in oral squamous cell carcinoma. However, regional lymph node metastasis from oral cancer has barely been investigated in 4-nitroquinoline-1-oxide (4NQO) models. In this study, we developed a 4NQO-treated mouse
Ting-Hui Chu et al.
Cancer letters, 337(1), 115-124 (2013-06-04)
miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211
实验方案
Chlorobenzilate; 4-Aminobiphenyl; 2-Fluorobiphenyl; N-Nitrosopyrrolidine; 1,2,4,5-Tetrachlorobenzene; 3-Methylcholanthrene; Phenacetin
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