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Merck
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Key Documents

SRP6172

Sigma-Aldrich

IL-4 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinónimos:

B-cell stimulatory factor 1 (BSF-1), BCGF, Binetrakin, Lymphocyte stimulatory factor 1, Pitrakinra

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in HEK 293 cells

Análisis

≥95% (SDS-PAGE)

formulario

lyophilized

mol peso

(14 and 19 kDa, monomer)

envase

pkg of 10 μg

técnicas

cell culture | mammalian: suitable

Nº de acceso NCBI

P05112

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... IL4(3565)

Descripción general

Interleukin-4 (IL-4) is a pleiotropic cytokine and a potent lymphoid cell growth factor. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The gene encoding this protein is localized on human chromosome 5q31.1. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Acciones bioquímicas o fisiológicas

Interleukin-4 (IL-4) stimulates the growth and survivability of certain B cells and T cells. The interleukin 4 receptor also binds to interleukin-13 (IL-13), which may contribute to many overlapping functions of this cytokine and IL-13. STAT6 (signal transducer and activator of transcription-6) has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This protein exhibits anti-inflammatory responses and has a role in immune processes by protecting against intracellular pathogens.

Forma física

Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.

Nota de preparación

Centrifuge the vial prior to opening.

Reconstitución

Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Interleukin 4 mediates autocrine growth of helper T cells after antigenic stimulation.
Fernandez-Botran R
Proceedings of the National Academy of Sciences of the USA, 83(24), 9689-9693 (1986)
Interleukin 4 inhibition as a potential therapeutic in pemphigus.
Tavakolpour S and Tavakolpour V
Cytokine, 77, 189-195 (2016)
D G Marsh et al.
Science (New York, N.Y.), 264(5162), 1152-1156 (1994-05-20)
Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (IgE) concentration. No linkage was found between these markers and specific IgE antibody
Masanori Kobayashi et al.
Cancer immunology, immunotherapy : CII, 63(8), 797-806 (2014-04-30)
Dendritic cell (DC)-based cancer vaccines may have a significant benefit to patients with advanced pancreatic cancer. However, variations among clinical studies make it difficult to compare clinical outcomes. Here, we identified factors that determined the clinical benefits by analyzing data
Michelle A Favila et al.
Journal of immunology (Baltimore, Md. : 1950), 192(12), 5863-5872 (2014-05-09)
Leishmania major-infected human dendritic cells (DCs) exhibit a marked induction of IL-12, ultimately promoting a robust Th1-mediated response associated with parasite killing and protective immunity. The host cell transcription machinery associated with the specific IL-12 induction observed during L. major
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