H7291
Interleukin-4 human
IL-4, potency:, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
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About This Item
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in HEK 293 cells
Ensayo
>95% (SDS-PAGE)
Formulario
lyophilized powder
potencia
≤0.6 ng/mL EC50
calidad
endotoxin tested
mol peso
dimer 14-19 kDa (glycosylated)
envase
pkg of 1 mg
pkg of 10 μg
pkg of 100 μg
fabricante / nombre comercial
HumanZyme
técnicas
cell culture | mammalian: suitable
impurezas
<1 EU/μg
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... IL4(3565)
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Descripción general
Interleukin-4 (IL-4) is a pleiotropic cytokine and a complex glycoprotein mapped to human chromosome 5q31.1. It is produced by mast cells, basophils and a subset of activated T cells.
Acciones bioquímicas o fisiológicas
Interleukin-4 (IL-4) interacts with interleukin 13 and is an interleukin-4 receptor ligand. It regulates IgE and IgG1 production by B cells. IL-4 favors glial and neuronal differentiation and regulates differentiation of naive cluster of differentiation CD4+ T cells to the T helper type 2 (TH2) cells. Polymorphism in the IL-4 gene is implicated in immune and inflammatory disorders. In cerebral infarction, IL-4 levels are elevated.
Forma física
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Nota de preparación
HumanKine Interleukin-4 (IL-4), expressed in human HEK 293 cells, is a glycosylated monomer with an apparent molecular mass of 14-19 kDa due to glycosylation, which is absent when this cytokine is expressed in E. coli. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Nota de análisis
The activity is determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Información legal
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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