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Merck

I4269

Sigma-Aldrich

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinónimos:

IL-4, hIL-4

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About This Item

Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

product name

Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

origen biológico

human

Nivel de calidad

recombinante

expressed in E. coli

Análisis

≥98% (SDS-PAGE)

formulario

lyophilized powder

potencia

≤0.400 ng/mL EC50

calidad

endotoxin tested

mol peso

14.9 kDa (containing 129 amino acid residues)

envase

pkg of 5 and 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

≤1.000 EU/μg

color

white

Nº de acceso UniProt

temp. de almacenamiento

−20°C

Información sobre el gen

human ... IL4(3565)
mouse ... IL4(3565)

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Descripción general

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.3

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.4

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.5

Aplicación

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

Forma física

Lyophilized from a sterile filtered solution.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Cita

1. Paul, W.E., Interleukin-4: a prototypic immuno-regulatory lymphokine. Blood, 77, 1859-1870 (1991).
2. O′Garra, A., and Arai, N., The molecular basis of T helper 1 and T helper 2 cell differentiation. Trends Cell Biol., 10, 542-550 (2000).
3. Ryan, J.J. et al., Mast cell homeostasis: a fundamental aspect of allergic disease. Crit. Rev. Immunol., 27, 15-32 (2007).
4. Callard, R.E. et al., IL-4 and IL-13 receptors: are they one and the same? Immunol. Today, 17, 108-110 (1996).
5. Yokota, T. et al., Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. Immunol. Rev., 102, 137-187 (1988).
6. Kitamura, T. et al., Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J. Cell Physiol., 140, 323-334 (1989).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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