I4269

IL-4 human

≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Sinónimos: IL-4, Interleukin-4 human, hIL-4
• Número MDL: MFCD00151705
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• Nombre del producto: Interleukin-4 human, IL-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• origen biológico: human
• Nivel de calidad: 200
• recombinante: expressed in E. coli
• Ensayo: ≥98% (SDS-PAGE)
• Formulario: lyophilized powder
• potencia: ≤0.400 ng/mL EC₅₀
• calidad: endotoxin tested
• mol peso: 14.9 kDa (containing 129 amino acid residues)
• envase: pkg of 5 and 50 μg
• técnicas: cell culture | mammalian: suitable
• impurezas: ≤1.000 EU/μg
• color: white
• Nº de acceso UniProt: P05112
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... IL4(3565) ; mouse ... IL4(3565)

Descripción

Descripción general

Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including differentiation of naive T cells into the TH2 phenotype, promoting B cell proliferation, antibody isotype switching, and expression of other TH2 cytokines including IL-5 and IL-9.^1,2 IL-4 plays a critical role in the development of allergic inflammation and asthma.³

IL-4 binds to two distinct receptors; the type I receptor, a heterodimer consisting of the IL-4Rα chain and the common gamma chain, γc, and the type II receptor, a heterodimer of IL-4Rα and IL-13Rα1.⁴

Naturally occurring IL-4 has a molecular mass of 12-20 kDa. Recombinant human IL-4 is a 14.9 kDa protein containing 129 amino acid residues. Human and mouse IL-4 share a 50% amino acid sequence homology, but their biological actions are species-specific.⁵

Aplicación

Lymphokine with profound effects on the growth and differentiation of immunologically competent cells, inhibits VEGF-induced and βFGF-induced angiogenesis.

Forma física

Lyophilized from a sterile filtered solution.

Nota de análisis

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable