H6916

Macrophage Colony-Stimulating Factor human

M-CSF, recombinant, expressed in HEK 293 cells, suitable for cell culture

• Sinónimos: MCSF
• Número MDL: MFCD00166591
• Código UNSPSC: 12352202
• NACRES: NA.77

Propiedades

• origen biológico: human
• Nivel de calidad: 100
• recombinante: expressed in HEK 293 cells
• Análisis: ≥95% (SDS-PAGE)
• formulario: lyophilized powder
• potencia: ≤4 ng/mL EC₅₀
• calidad: endotoxin tested
• mol peso: dimer 35-40 kDa (glycosylated)
• envase: pkg of 10 μg
• fabricante / nombre comercial: HumanZyme
• técnicas: cell culture | mammalian: suitable
• Nº de acceso UniProt: P09603
• temp. de almacenamiento: −20°C
• Información sobre el gen: human ... CSF1(1435)

Descripción

Descripción general

M-CSF is encoded by the gene mapped to human chromosome 1p13.3. It is a glycosylated polypeptide, which exists as a homodimer. M-CSF is produced by macrophage, fibroblasts, lymphocyte and endothelial cells.

Acciones bioquímicas o fisiológicas

Macrophage CSF (M-CSF) as a growth factor, stimulates the proliferation and differentiation of monocyte/macrophage-lineage cells. It also boosts antibody-dependent, cell-mediated cytotoxicity by monocytes and macrophages. In addition, human M-CSF inhibits bone resorption by osteoclasts. It might also play a crucial role in atherosclerosis. Overexpression of the gene has been observed in Paget′s disease of bone (PDB).

Forma física

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Nota de análisis

The specific activity was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells (mouse myeloid Leukemia indicator cell line).

Cita

1. Mazur, E.M., and Cohen, J.L., Clin. Pharmacol. Ther., 46, 250 (1989).
2. Morstyn, G., and Burgess, A.W., Cancer Res., 48, 5624 (1988).
3. Metcalf, D., Blood, 67, 257 (1986).
4. Mufson, R.A., et al., Cell. Immunol., 119, 182 (1989).
5. Hattersley, G., et al., J. Cell Physiol., 137, 199 (1988).

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable