L4391
Lipopolysaccharides from Escherichia coli O111:B4
γ-irradiated, BioXtra, suitable for cell culture
Sinónimos:
LPS
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About This Item
Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352211
NACRES:
NA.75
Productos recomendados
origen biológico
Escherichia coli (O111:B4)
Nivel de calidad
esterilidad
γ-irradiated
Línea del producto
BioXtra
Formulario
lyophilized powder
purificado por
gel-filtration chromatography
condiciones de almacenamiento
desiccated
técnicas
cell based assay: suitable
cell culture | mammalian: suitable
impurezas
<1% Protein (Lowry)
solubilidad
H2O: 5 mg/mL, slightly hazy
aplicaciones
clinical research
life science and biopharma
temp. de almacenamiento
2-8°C
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Descripción general
Lipopolysaccharides (LPS) are intricate molecules consisting of lipids and polysaccharides, predominantly present in the outer membrane of Gram-negative bacteria. Comprising lipid A, the core oligosaccharide (core), and the O-specific polysaccharide or O antigen (OAg), LPS is anchored to the outer bacterial membrane, with lipid A primarily responsible for its associated toxicity. Functioning as a potent activator of the proinflammatory response, LPS engages various mammalian cells, including macrophages, monocytes, and endothelial cells. While serving a protective role for Gram-negative bacteria against environmental stress, LPS also triggers recognition by the innate immune system during infections.
Aplicación
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
This LPS serotype has been used to stimulate B-cells and induce NOS in human hepatocytes.
Acciones bioquímicas o fisiológicas
LPS is a major constituent of the cell wall of most gram negative bacteria. It is a highly immunogenic antigen with the ability to enhance immune responses to soluble antigens. LPS also acts as a specific mitogen for bone marrow derived B lymphocytes from mice, rabbits, chickens, cows, hamsters, and humans.
Características y beneficios
- High-purity compound suitable for a wide variety of research applications
Reconstitución
Lipopolysaccharides are supplied as lyophilized, γ-irradiated powders. To reconstitute, add 1 ml sterile balanced salt solution or tissue culture medium to the vial (1 mg) and gently swirl until the powder dissolves. Reconstituted product may be further diluted to desired working concentrations using sterile balanced salt solution or tissue culture medium.
Otras notas
For additional information on our range of Biochemicals, please complete this form.
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 2 Oral
Código de clase de almacenamiento
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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